Chen G S, Chang C S, Kan W M, Chang C L, Wang K C, Chern J W
J Med Chem. 2001 Nov 8;44(23):3759-63. doi: 10.1021/jm010433s.
A hypothetical pharmacophore of 5 alpha-reductase inhibitors was generated and served as a template in virtual screening. When the pharmacophore was used, eight isoflavone derivatives were characterized as novel potential nonsteroidal inhibitors of rat 5 alpha-reductase. This investigation has demonstrated a practical approach toward the development of lead compounds through a hypothetic pharmacophore via three-dimensional database searching.
