Bulik C M, Prescott C A, Kendler K S
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, PO Box 980126, Richmond, VA 23298-0126, USA.
Br J Psychiatry. 2001 Nov;179:444-9. doi: 10.1192/bjp.179.5.444.
Childhood sexual abuse (CSA) is associated with an increased risk of subsequent psychiatric disorders.
To explore the risk associated with features of CSA and examine whether specific associations exist between particular profiles of CSA and the development of specific syndromes.
In a population-based sample of adult female twins, we used logistic regression to explore the association between features of CSA (reported by the twin and her co-twin) and lifetime major depression, generalised anxiety disorder, bulimia nervosa, panic disorder and alcohol and drug dependence.
In univariate and stepwise multiple regressions, patterns of predictors differed, although not significantly, across diagnoses. Greater risk was associated with attempted or completed intercourse, the use of force or threats, abuse by a relative, and a negative response by someone who was told about the abuse. Similar patterns were observed with co-twin reports.
Specific features of CSA differentially increase risk of later psychopathology; however, there do not appear to be unique predictive relationships between features of CSA and the emergence of specific psychiatric disorders.
儿童期性虐待（CSA）与后续精神疾病风险增加相关。
探讨与CSA特征相关的风险，并检查CSA的特定特征与特定综合征的发展之间是否存在特定关联。
在基于人群的成年女性双胞胎样本中，我们使用逻辑回归来探讨CSA特征（由双胞胎及其同卵双胞胎报告）与终生重度抑郁症、广泛性焦虑症、神经性贪食症、恐慌症以及酒精和药物依赖之间的关联。
在单变量和逐步多元回归中，预测因素模式在不同诊断之间存在差异，尽管差异不显著。更高的风险与尝试或完成性交、使用武力或威胁、亲属虐待以及被告知虐待事件的人给出负面反应有关。同卵双胞胎报告也观察到类似模式。
CSA的特定特征会不同程度地增加后期精神病理学风险；然而，CSA特征与特定精神疾病的出现之间似乎不存在独特的预测关系。
