Keogh B, Hreshchyshyn M M, Moore R H, Merrin C E, Murphy G P
Urology. 1975 Apr;5(4):496-503. doi: 10.1016/0090-4295(75)90074-6.
Ninety-three cases of germinal testicular tumors with urinary gonadotropin (HCG) values, estimated by biologic or radioimmunoassay techniques, were reviewed. Preoperative values of HCG and subsequent postoperative values were related to response to treatment and prognosis. Twenty-five patients (26.9 per cent) comprised the seminoma group, and 68 patients (73.1 per cent) the nonseminomatous groups of germinal neoplasms. High HCG values were observed in the nonseminomatous group pre- and postoperatively by both assay procedures. Most significant was the high HCG values postoperatively (p smaller than 0.05, x2 equals 5.21 and p smaller than 0.05, x2 equals 5.23) for the biologic assay and radioimmunoassay, respectively, with high HCG values being associated with a poor cumulative 24 per cent two-year survival rate. Urinary HCG assay is of prognostic value in the ongoing management of testicular neoplasms. In the future, serum HCG assays may be of additional benefit.
回顾了93例通过生物学或放射免疫测定技术估算尿促性腺激素（HCG）值的原发性睾丸肿瘤病例。术前HCG值及随后的术后值与治疗反应和预后相关。25例患者（26.9%）为精原细胞瘤组，68例患者（73.1%）为非精原细胞瘤性生殖肿瘤组。两种检测方法在非精原细胞瘤组术前和术后均观察到高HCG值。最显著的是，生物学检测和放射免疫测定术后的HCG值分别较高（p小于0.05，x²等于5.21；p小于0.05，x²等于5.23），高HCG值与24%的两年累积生存率低相关。尿HCG检测在睾丸肿瘤的持续管理中具有预后价值。未来，血清HCG检测可能会有更多益处。
