普萘洛尔输注对妊娠绵羊脐循环和子宫循环的影响。
Effect of propranolol infusion on the umbilical and uterine circulations of pregnant sheep.
作者信息
Oakes G K, Walker A M, Ehrenkranz R A, Chez R A
出版信息
Am J Obstet Gynecol. 1976 Dec 15;126(8):1038-42. doi: 10.1016/0002-9378(76)90698-0.
Propranolol was infused intravenously for 60 minutes to five ewes (4 mug per kilogram per minute) or five fetal sheep (10 mug per kilogram per minute). The umbilical blood flow was significantly decreased by 18 per cent from control at 60 minutes with either maternal or fetal propranolol infusion. Uterine blood flow and maternal and fetal mean arterial pressure did not significantly change. Maternal and fetal heart rates decreased 18 and 9 per cent from control, respectively, during maternal propranolol infusion. With propranolol to the fetus, fetal heart rate decreased 15 per cent and maternal heart rate did not change. During all infusion, maternal and fetal arterial pH, PCO2 and PO2 remained within normal physiologic limits.
对五只母羊（每分钟每千克4微克）或五只胎羊（每分钟每千克10微克）静脉输注普萘洛尔60分钟。在母羊或胎羊输注普萘洛尔后60分钟时，脐血流量较对照组显著降低了18%。子宫血流量以及母羊和胎羊的平均动脉压均无显著变化。在母羊输注普萘洛尔期间，母羊和胎羊心率分别较对照组降低了18%和9%。给胎羊输注普萘洛尔时，胎羊心率降低了15%，母羊心率未变。在所有输注过程中，母羊和胎羊的动脉pH值、PCO₂和PO₂均保持在正常生理范围内。
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