非诺特罗（Th1165a）输注对妊娠绵羊子宫和脐血流的影响。
Effect of fenoterol (Th1165a) infusion on uterine and umbilical blood flow in pregnant sheep.
作者信息
Ehrenkranz R A, Walker A M, Oakes G K, Hamilton L A, Chez R A
出版信息
Am J Obstet Gynecol. 1977 May 15;128(2):177-82. doi: 10.1016/0002-9378(77)90683-4.
The effect of fenoterol (Th1165a) upon uterine artery blood flow (UtBF) and umbilical vein blood flow (UmBF) was investigated in near-term, nonlaboring chronic sheep preparations. During intravenous fenoterol infusions to the ewe in either incremental doses from 0.025 to 0.200 microng per kilogram per minute or constant infusions of 0.025 microng per kilogram per minute for 120 minutes. UtBF and UmBF did not change significantly. Dose-related maternal tachycardia, hyperglycemia, and relative acidemia occurred, but there were no significant changes in mean maternal and fetal arterial pressures or fetal heart rate. The simultaneous infusion of propranolol (2 microng per kilogram per minute) with fenoterol (0.200 microng per kilogram per minute) blocked the maternal tachycardia but resulted in a significant decrease in UmBF and a significant increase in UtBF. In all of the maternal infusions. UtBF significantly rose and plateaued up to 14 per cent above the control level during the 120 minute recovery period after infusion. A non-beta-adrenergic effect of fenoterol is suggested as the cause of this UtBF increase.
在接近足月、未临产的慢性绵羊实验准备中，研究了非诺特罗（Th1165a）对子宫动脉血流（UtBF）和脐静脉血流（UmBF）的影响。在向母羊静脉输注非诺特罗时，采用两种方式：一是以每分钟每千克0.025至0.200微克的递增剂量输注，二是持续以每分钟每千克0.025微克的剂量输注120分钟。UtBF和UmBF均无显著变化。出现了与剂量相关的母体心动过速、高血糖和相对性酸血症，但母体和胎儿平均动脉压及胎儿心率均无显著变化。非诺特罗（每分钟每千克0.200微克）与普萘洛尔（每分钟每千克2微克）同时输注时，可阻断母体心动过速，但导致UmBF显著降低，UtBF显著升高。在所有母体输注过程中，输注后120分钟的恢复期内，UtBF显著升高并稳定在比对照水平高14%的水平。提示非诺特罗的非β - 肾上腺素能效应是UtBF升高的原因。
Zotero 插件