Osborn E, Baum J L, Ernst C, Koch P
Am J Ophthalmol. 1976 Nov;82(5):775-80. doi: 10.1016/0002-9394(76)90016-7.
We determined the relative potencies of penicillin G, carbenicillin, oxacillin, cephalothin, cephaloridine, gentamicin, kanamycin, neomycin, vancomycin, and bacitracin after their addition to three commercially available 0.5% hydroxypropyl methylcellulose artificial tear solutions in plastic squeeze bottles. We found no significant loss of antibiotic activity at room temperature over a period of seven days for all antibiotics except penicillin G, cephalothin, and cephaloridine. Three of the antibiotics were insoluble in one or more of the artificial tear solutions.
我们将青霉素G、羧苄青霉素、苯唑西林、头孢噻吩、头孢啶、庆大霉素、卡那霉素、新霉素、万古霉素和杆菌肽添加到三种市售的塑料挤压瓶装0.5%羟丙基甲基纤维素人工泪液中，测定了它们的相对效价。我们发现，除青霉素G、头孢噻吩和头孢啶外，所有抗生素在室温下放置7天期间其抗菌活性均无显著损失。其中三种抗生素在一种或多种人工泪液中不溶。
