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骨桥蛋白通过诱导朗格汉斯细胞和树突状细胞迁移至淋巴结，参与皮肤接触性超敏反应的启动。

Osteopontin is involved in the initiation of cutaneous contact hypersensitivity by inducing Langerhans and dendritic cell migration to lymph nodes.

作者信息

Weiss J M, Renkl A C, Maier C S, Kimmig M, Liaw L, Ahrens T, Kon S, Maeda M, Hotta H, Uede T, Simon J C

机构信息

Department of Dermatology, University of Freiburg, D-79104 Freiburg, Germany.

出版信息

J Exp Med. 2001 Nov 5;194(9):1219-29. doi: 10.1084/jem.194.9.1219.

DOI:10.1084/jem.194.9.1219
PMID:11696588
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2195976/
Abstract

Osteopontin (OPN) is a chemotactic protein that attracts immune cells, to inflammatory sites. The sensitization phase of allergic cutaneous contact hypersensitivity (CHS) requires the migration of Langerhans cells/dendritic cells (LCs/DCs) from skin to draining lymph nodes. Characterizing OPN function for LC/DC migration we found upregulated OPN expression in hapten sensitized skin and draining lymph nodes. OPN induces chemotactic LC/DC migration, initiates their emigration from the epidermis, and attracts LCs/DCs to draining lymph nodes by interacting with CD44 and alphav integrin. Furthermore, OPN-deficient mice have a significantly reduced CHS response that correlates with an impaired ability of OPN-deficient mice to attract LCs/DCs to draining lymph nodes. In conclusion, OPN is an important factor in the initiation of CHS by guiding LCs/DCs from skin into lymphatic organs.

摘要

骨桥蛋白（OPN）是一种趋化蛋白，可将免疫细胞吸引至炎症部位。过敏性皮肤接触性超敏反应（CHS）的致敏阶段需要朗格汉斯细胞/树突状细胞（LCs/DCs）从皮肤迁移至引流淋巴结。在研究OPN对LC/DC迁移的作用时，我们发现半抗原致敏的皮肤和引流淋巴结中OPN表达上调。OPN可诱导LC/DC的趋化性迁移，促使其从表皮迁出，并通过与CD44和αv整合素相互作用将LCs/DCs吸引至引流淋巴结。此外，OPN缺陷小鼠的CHS反应显著降低，这与OPN缺陷小鼠将LCs/DCs吸引至引流淋巴结的能力受损有关。总之，OPN是引导LCs/DCs从皮肤进入淋巴器官从而启动CHS的重要因素。

相似文献

[1]
Osteopontin is involved in the initiation of cutaneous contact hypersensitivity by inducing Langerhans and dendritic cell migration to lymph nodes.

J Exp Med. 2001-11-5

[2]
Alpha 6 integrins are required for Langerhans cell migration from the epidermis.

J Exp Med. 1997-11-17

[3]
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Oncotarget. 2016-6-21

[4]
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J Immunol. 2004-4-1

[5]
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J Immunol. 2003-5-15

[6]
Enhanced epidermal Langerhans cell migration in IL-10 knockout mice.

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[7]
Dermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response.

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[8]
CD40-CD40 ligand interactions in vivo regulate migration of antigen-bearing dendritic cells from the skin to draining lymph nodes.

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[9]
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[10]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks.

Immunol Today. 2000-10

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J Cell Biochem. 2000-4

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Br J Dermatol. 2000-3

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Science. 2000-2-4

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Analysis of mouse dendritic cell migration in vivo upon subcutaneous and intravenous injection.

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Infect Immun. 1999-8

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Detection of various epitopes of murine osteopontin by monoclonal antibodies.

Biochem Biophys Res Commun. 1999-4-2

[8]
CD44 is not an adhesive receptor for osteopontin.

J Cell Biochem. 1999-4-1

[9]
Osteopontin is associated with T cells in sarcoid granulomas and has T cell adhesive and cytokine-like properties in vitro.

J Immunol. 1999-1-15

[10]
Langerhans cells and chemical allergy.

Curr Opin Immunol. 1998-12

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