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优化后的金缕梅（金缕梅科）花提取物可抑制破骨细胞分化。

Optimized Extract from Uyeki (Hamamelidaceae) Flos Inhibits Osteoclast Differentiation.

作者信息

Lee Yongjin, Kim Jung-Eun, Kim Kwang-Jin, Cho Seung-Sik, Son Young-Jin

机构信息

Department of Pharmacy, Sunchon National University, Jeonnam, Suncheon 57922, Republic of Korea.

Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan, Jeonnam 58554, Republic of Korea.

出版信息

Evid Based Complement Alternat Med. 2018 Mar 6;2018:6302748. doi: 10.1155/2018/6302748. eCollection 2018.

DOI:10.1155/2018/6302748
PMID:29692856
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5859845/
Abstract

Osteoporosis is a metabolic disorder that decreases the stability against fractures of the spine, femur, and radius by weakening the strength and integrity of bones. Receptor activator of nuclear factor-kappa B ligand signaling ultimately activated nuclear factor-activated T cells c1, a major transcription factor for osteoclast formation. This study researched the effects of Uyeki flos extracts on the antiosteoclastic potential of macrophages and the phytochemicals contained therein. The alcoholic extract of Uyeki flos inhibited the differentiation of osteoclast. We carried out the experiments of the pattern of differentiation of osteoclasts based on the alcoholic percentage of extracts. Among them, 80% alcoholic extract showed the highest inhibitory effect. The alcoholic extract was composed of phytochemicals such as bergenin, quercetin, and quercitrin. This extract inhibited not only mRNA expression levels of NFATc1, osteoclast-associated receptor (OSCAR), cathepsin K, and tartrate-resistant acid phosphatase (TRAP), but also the translational expression of NFATc1. The inhibitory effect for osteoclast differentiation of the alcoholic extract was confirmed using the resorption pit assay. This is the first scientific report of the antiosteoclastic effects of Uyeki flos extract, which can be applied therapeutically for the treatment of osteoporosis.

摘要

骨质疏松症是一种代谢紊乱疾病，它通过削弱骨骼的强度和完整性，降低脊柱、股骨和桡骨对骨折的抵抗力。核因子κB受体活化因子配体信号最终激活核因子活化T细胞c1，这是破骨细胞形成的主要转录因子。本研究探讨了雪柳花提取物对巨噬细胞抗破骨细胞潜能及其所含植物化学物质的影响。雪柳花乙醇提取物抑制破骨细胞分化。我们根据提取物的乙醇含量进行了破骨细胞分化模式的实验。其中，80%乙醇提取物显示出最高的抑制作用。乙醇提取物由岩白菜素、槲皮素和槲皮苷等植物化学物质组成。该提取物不仅抑制核因子活化T细胞c1、破骨细胞相关受体（OSCAR）、组织蛋白酶K和抗酒石酸酸性磷酸酶（TRAP）的mRNA表达水平，还抑制核因子活化T细胞c1的翻译表达。通过吸收陷窝试验证实了乙醇提取物对破骨细胞分化的抑制作用。这是关于雪柳花提取物抗破骨细胞作用的首篇科学报道，其可用于骨质疏松症的治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/157c/5859845/2ea4364a2c3f/ECAM2018-6302748.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/157c/5859845/4769706db460/ECAM2018-6302748.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/157c/5859845/ba5bb1627b25/ECAM2018-6302748.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/157c/5859845/a40082074c8c/ECAM2018-6302748.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/157c/5859845/314536a07ff6/ECAM2018-6302748.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/157c/5859845/2ea4364a2c3f/ECAM2018-6302748.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/157c/5859845/4769706db460/ECAM2018-6302748.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/157c/5859845/ba5bb1627b25/ECAM2018-6302748.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/157c/5859845/a40082074c8c/ECAM2018-6302748.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/157c/5859845/314536a07ff6/ECAM2018-6302748.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/157c/5859845/2ea4364a2c3f/ECAM2018-6302748.005.jpg

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