Molica S
Department Hematology/Oncology, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy.
Leuk Lymphoma. 2001 Aug;42(4):603-7. doi: 10.3109/10428190109099320.
Recent studies indicate that angiogenesis may be involved in the pathogenesis of certain hematological malignancies. However as far as B-cell chronic lymphocytic leukemia (CLL) is concerned, current data dealing with the evaluation of bone marrow (BM) microvessel density, a marker of angiogenesis grade, do not as yet provide definitive results. It is now clear that the mRNA isoforms VEGF121 and VEGF 165 are expressed by B-CLL cells. In addition, low cellular and high serum levels of VEGF correlated with a poor clinical outcome. Although these data do not as yet show that angiogenesis is essential for B-CLL, it may indeed be relevant in the leukemic process so characteristic of this diseases.
最近的研究表明，血管生成可能参与某些血液系统恶性肿瘤的发病机制。然而，就B细胞慢性淋巴细胞白血病（CLL）而言，目前关于评估骨髓微血管密度（血管生成分级的一个标志物）的数据尚未提供明确的结果。现在已经明确，B - CLL细胞表达mRNA异构体VEGF121和VEGF 165。此外，VEGF的低细胞水平和高血清水平与不良临床结果相关。尽管这些数据尚未表明血管生成对B - CLL至关重要，但它在这种疾病特有的白血病过程中可能确实具有相关性。
