Al-Bahlani S, Sherriff A, Crawford P J
Department of Oral and Dental Science, University of Bristol, UK.
J R Coll Surg Edinb. 2001 Oct;46(5):261-4.
Local anaesthesia is used routinely in dental surgery; it is effective in both pain control and--through the vasoconstrictors often contained within it--the reduction of bleeding. The extraction of deciduous teeth under general anaesthesia is often carried out without these local effects. There are no previous studies to investigate the combined effect of local anaesthesia with general anaesthesia on blood loss and pain control. A randomised, controlled clinical trial was carried out with one hundred children aged 3-5 years. Ethical approval and informed consent were obtained. Surface anaesthetic cream (EMLA) was placed on the hand into which the intravenous access was to be placed. One to two ml of blood was taken at the time of induction as a baseline of the patient's level of haematin pigment. Children in the experimental group were given one quarter of a cartridge (0.5 ml) of local anaesthetic containing epinephrine (1:80,000) in each quadrant before tooth extraction; all blood in swabs, suction equipment and disposables was collected and digested with NaOH. The children were observed for 11 minutes post-operatively for any signs of distress. Total blood loss was calculated by comparison of the baseline sample and the shed blood digests. This study showed that using local anaesthesia for dental extractions under general anaesthesia was associated with decreased blood loss (p = 0.001). The second finding--which has not been reported before--was that this use of local anaesthesia was shown to cause distress to this age group of children upon recovery from the general anaesthetic (p <0.0001). The use of local anaesthetic in this situation provided a useful reduction in post-operative bleeding. However, its use was associated with greater post-operative distress.
局部麻醉在牙科手术中常规使用;它在控制疼痛以及(通过其通常含有的血管收缩剂)减少出血方面均有效。在全身麻醉下拔除乳牙时,通常没有这些局部效应。以前没有研究调查局部麻醉与全身麻醉联合使用对失血和疼痛控制的综合影响。对100名3至5岁的儿童进行了一项随机对照临床试验。获得了伦理批准和知情同意。将表面麻醉乳膏(复方利多卡因乳膏)涂在要进行静脉穿刺的手上。诱导时采集1至2毫升血液作为患者血红蛋白水平的基线。实验组的儿童在拔牙前每个象限给予四分之一支(0.5毫升)含肾上腺素(1:80,000)的局部麻醉剂;收集拭子、吸引设备和一次性用品中的所有血液,并用氢氧化钠消化。术后观察儿童11分钟,观察是否有痛苦迹象。通过比较基线样本和失血消化物来计算总失血量。这项研究表明,在全身麻醉下进行拔牙时使用局部麻醉与失血量减少有关(p = 0.001)。第二个发现——以前未曾报道过——是这种局部麻醉的使用在儿童从全身麻醉恢复后会导致这个年龄组的儿童出现痛苦(p <0.0001)。在这种情况下使用局部麻醉剂可有效减少术后出血。然而,其使用与更大的术后痛苦有关。