Kaiser J, Lutzenberger W
MEG-Center, Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Gartenstrasse 29, 72074 Tübingen, Germany.
Neurosci Lett. 2001 Nov 13;314(1-2):17-20. doi: 10.1016/s0304-3940(01)02248-0.
Auditory mismatch negativity, the brain's change-detection response, has been shown to be more sensitive than other early auditory cortex responses to the hemispheric specialization of speech processing. The present study used magnetoencephalography to assess hemispheric differences in cortical evoked responses during auditory spatial processing. We compared N1m to lateralized vowels presented with equal probabilities with mismatch fields (MMNm) to rare lateralized noises interspersed in a sequence of frequent midline sounds. Both N1m and MMNm dipole amplitudes were higher in the hemisphere contralaterally to the side of sound lateralization, but this effect was about four times bigger in the mismatch paradigm. Moreover, only MMNm dipoles showed shorter latencies in the hemisphere contralaterally to stimulation. Apparently stimulus changes activate specialized auditory networks more strongly than non-deviant events.
听觉失配负波，即大脑的变化检测反应，已被证明比其他早期听觉皮层反应对言语处理的半球特化更敏感。本研究使用脑磁图来评估听觉空间处理过程中皮层诱发反应的半球差异。我们将以相等概率呈现的侧向化元音的N1m与穿插在一系列频繁中线声音中的罕见侧向化噪声的失配场（MMNm）进行了比较。声音侧向化一侧对侧半球的N1m和MMNm偶极子振幅均较高，但在失配范式中这种效应大约大四倍。此外，只有MMNm偶极子在刺激对侧半球的潜伏期较短。显然，与非偏差事件相比，刺激变化更强烈地激活了专门的听觉网络。
