Bartek J, Lukas J
Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.
Curr Opin Cell Biol. 2001 Dec;13(6):738-47. doi: 10.1016/s0955-0674(00)00280-5.
The ability to preserve genomic integrity is a fundamental feature of life. Recent findings regarding the molecular basis of the cell-cycle checkpoint responses of mammalian cells to genotoxic stress have converged into a two-wave concept of the G1 checkpoint, and shed light on the so-far elusive intra-S-phase checkpoint. Rapidly operating cascades that target the Cdc25A phosphatase appear central in both the initiation wave of the G1 checkpoint (preceding the p53-mediated maintenance wave) and the transient intra-S-phase response. Multiple links between defects in the G1/S checkpoints, genomic instability and oncogenesis are emerging, as are new challenges and hopes raised by this knowledge.
维持基因组完整性的能力是生命的一项基本特征。最近有关哺乳动物细胞对基因毒性应激的细胞周期检查点反应分子基础的研究结果，形成了G1检查点的两波概念，并揭示了迄今为止难以捉摸的S期内检查点。针对Cdc25A磷酸酶的快速运作级联反应，在G1检查点的起始波（先于p53介导的维持波）和短暂的S期内反应中似乎都起着核心作用。G1/S检查点缺陷、基因组不稳定与肿瘤发生之间的多种联系正在显现，这些知识也带来了新的挑战和希望。
