对抗细胞衰老的抗氧化策略：在一项系统评价中揭示合成抗氧化剂与天然抗氧化剂的功效

Antioxidant strategies against cellular senescence: unveiling the power of synthetic versus natural antioxidants in a systematic review.

作者信息

Ebrahimirad Farbod, Mirmahdizade Seyedeh Elahe, Mahmoodieh Bahar, Najafi Saina, Banihashemian Seyedeh Marzieh, Nikakhtar Sadegh, Mobaraki Hesam, Sadeghi Asma, Kossari Naghmeh, SadatRafiei Seyyed Kiarash, Ghodsi Moghadam Masood, Mashkani Ali, Asadi Anar Mahsa, Khosravi Farbod

机构信息

Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Department of Food Science and Technology, Science and Research Branch, Islamic Azad University, Tehran, Iran.

出版信息

Front Aging. 2025 May 27;6:1543360. doi: 10.3389/fragi.2025.1543360. eCollection 2025.

DOI:10.3389/fragi.2025.1543360

PMID:40496803

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12149200/

Abstract

BACKGROUND

Cellular senescence, characterized by irreversible cell cycle arrest, plays a pivotal role in ageing and the development of age-related pathologies. Mitigating oxidative stress, a primary contributor to cellular ageing, is crucial for inhibiting the senescence-associated secretory phenotype (SASP). A comparative analysis of synthetic and natural antioxidants is necessary to evaluate the efficacy of synthetic and natural antioxidants in this context.

METHOD

A systematic review encompassed studies published up to July 2023, utilizing prominent databases such as PubMed, Google Scholar, Scopus, and Web of Science. To enhance the efficiency of data screening and selection, we employed Rayyan. ai, an advanced tool designed for systematic reviews.

RESULT

The review encompassed 33 studies examining the impact of diverse antioxidants on cellular senescence. Findings indicated that synthetic antioxidants, such as N-acetylcysteine, and natural alternatives, like Vitamin C, demonstrated efficacy in attenuating oxidative stress and senescence markers. Notably, natural antioxidants frequently exhibited comparable or superior efficacy to their synthetic counterparts in most studies. Furthermore, the synergistic effects of antioxidant combinations sometimes yield enhanced benefits. It is worth noting that certain recently developed synthetic compounds, such as MHY2233, have shown promising results, exhibiting greater potency than established antioxidants in mitigating senescence markers.

CONCLUSION

Dietary practices and the aging process can influence these intricate processes and how they interact, serving as potential primary and secondary preventative strategies. The Mediterranean diet, dietary antioxidants, and limiting calorie intake are promising nutritional strategies. Better insight into the molecular mechanisms of aging may facilitate the development of efficient biomarkers and antioxidants for diagnosis or treatment.

SYSTEMATIC REVIEW REGISTRATION

https://osf.io/b67wm/.

摘要

背景

细胞衰老以不可逆的细胞周期停滞为特征，在衰老及与年龄相关的病理发展中起关键作用。减轻氧化应激（细胞衰老的主要促成因素）对于抑制衰老相关分泌表型（SASP）至关重要。在此背景下，对合成抗氧化剂和天然抗氧化剂进行比较分析，对于评估它们的功效很有必要。

方法

一项系统综述涵盖了截至2023年7月发表的研究，利用了诸如PubMed、谷歌学术、Scopus和科学网等著名数据库。为提高数据筛选和选择的效率，我们使用了Rayyan.ai，这是一款专为系统综述设计的先进工具。

结果

该综述涵盖了33项研究，这些研究考察了多种抗氧化剂对细胞衰老的影响。研究结果表明，合成抗氧化剂如N-乙酰半胱氨酸以及天然替代品如维生素C，在减轻氧化应激和衰老标志物方面显示出功效。值得注意的是，在大多数研究中，天然抗氧化剂的功效常常与合成抗氧化剂相当或更优。此外，抗氧化剂组合的协同效应有时会带来更大益处。值得注意的是，某些最近开发的合成化合物，如MHY2233，已显示出有前景的结果，在减轻衰老标志物方面比已有的抗氧化剂效力更强。