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在警觉的猫进行经典条件反射期间,海马锥体细胞活动编码条件刺激的预测价值。

Hippocampal pyramidal cell activity encodes conditioned stimulus predictive value during classical conditioning in alert cats.

作者信息

Múnera A, Gruart A, Muñoz M D, Fernández-Mas R, Delgado-García J M

机构信息

División de Neurociencias, Laboratorio Andaluz de Biología, Universidad Pablo de Olavide, 41013 Seville, Spain.

出版信息

J Neurophysiol. 2001 Nov;86(5):2571-82. doi: 10.1152/jn.2001.86.5.2571.

Abstract

We have recorded the firing activities of hippocampal pyramidal cells throughout the classical conditioning of eyelid responses in alert cats. Pyramidal cells (n = 220) were identified by their antidromic activation from the ipsilateral fornix and according to their spike properties. Upper eyelid movements were recorded with the search coil in a magnetic field technique. Latencies and firing profiles of recorded pyramidal cells following the paired presentation of conditioned (CS) and unconditioned (US) stimuli were similar, regardless of the different sensory modalities used as CS (tones, air puffs), the different conditioning paradigms (trace, delay), or the different latency and topography of the evoked eyelid conditioned responses. However, for the three paradigms used here, evoked neuronal firing to CS presentation increased across conditioning, but remained unchanged for US presentation. Contrarily, pyramidal cell firing was not modified when the same stimuli used here as CS and US were presented unpaired, during pseudoconditioning sessions. Pyramidal cell firing did not seem to encode eyelid position, velocity, or acceleration for either reflex or conditioned eyelid responses. Evoked pyramidal cell responses were always in coincidence with a beta oscillatory activity in hippocampal extracellular field potentials. In this regard, the beta rhythm represents a facilitation, or permissive time window, for timed pyramidal cell firing. It is concluded that pyramidal cells encode CS-US associative strength or CS predictive value.

摘要

我们记录了警觉猫在眼睑反应经典条件反射过程中海马锥体细胞的放电活动。通过来自同侧穹窿的逆向激活及其锋电位特性鉴定了锥体细胞(n = 220)。使用磁场技术中的搜索线圈记录上眼睑运动。无论用作条件刺激(CS)的不同感觉模态(音调、吹气)、不同的条件反射范式(痕迹、延迟),还是诱发的眼睑条件反应的不同潜伏期和地形图如何,在条件刺激(CS)和非条件刺激(US)配对呈现后,所记录锥体细胞的潜伏期和放电模式都是相似的。然而,对于这里使用的三种范式,在条件反射过程中,对CS呈现诱发的神经元放电增加,但对US呈现则保持不变。相反,在伪条件反射实验中,当这里用作CS和US的相同刺激未配对呈现时,锥体细胞放电没有改变。锥体细胞放电似乎并未编码反射性或条件性眼睑反应的眼睑位置、速度或加速度。诱发的锥体细胞反应总是与海马细胞外场电位中的β振荡活动同时出现。在这方面,β节律代表了一个促进或允许的时间窗口,用于定时的锥体细胞放电。得出的结论是,锥体细胞编码CS-US关联强度或CS预测值。

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