尽管高效抗逆转录病毒疗法出现病毒学失败，但CD4细胞计数仍增加的患者体内的HIV-1耐药突变体。 - Suppr

Drug-resistant mutants of HIV-1 in patients exhibiting increasing CD4 cell count despite virological failure of highly active antiretroviral therapy.

作者信息

Antinori A, Liuzzi G, Cingolani A, Bertoli A, Di Giambenedetto S, Trotta M P, Rizzo M G, Girardi E, De Luca A, Perno C F

机构信息

Lazzaro Spallanzani National Institute for Infectious Diseases, IRCCS, Rome, Italy.

出版信息

AIDS. 2001 Nov 23;15(17):2325-7. doi: 10.1097/00002030-200111230-00017.

DOI:10.1097/00002030-200111230-00017

PMID:11698709

Abstract

摘要

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Drug-resistant mutants of HIV-1 in patients exhibiting increasing CD4 cell count despite virological failure of highly active antiretroviral therapy.尽管高效抗逆转录病毒疗法出现病毒学失败，但CD4细胞计数仍增加的患者体内的HIV-1耐药突变体。

AIDS. 2001 Nov 23;15(17):2325-7. doi: 10.1097/00002030-200111230-00017.

Immunological recovery despite virological failure is independent of human immunodeficiency virus-type 1 resistant mutants in children receiving highly active antiretroviral therapy.在接受高效抗逆转录病毒治疗的儿童中，尽管出现病毒学失败，但免疫恢复与1型人类免疫缺陷病毒耐药突变体无关。

J Med Virol. 2003 Aug;70(4):506-12. doi: 10.1002/jmv.10424.

Long-term suppression of plasma viremia with highly active antiretroviral therapy despite virus evolution and very limited selection of drug-resistant genotypes.尽管病毒发生了进化且耐药基因型的选择非常有限，但高效抗逆转录病毒疗法仍能长期抑制血浆病毒血症。

J Med Virol. 2004 Jul;73(3):350-61. doi: 10.1002/jmv.20098.

Emergence of drug resistance is associated with an increased risk of death among patients first starting HAART.在刚开始接受高效抗逆转录病毒治疗（HAART）的患者中，耐药性的出现与死亡风险增加相关。

PLoS Med. 2006 Sep;3(9):e356. doi: 10.1371/journal.pmed.0030356.

Discordant movement of CD4-positive T-cell count in HIV-1 infected patients with HAART failure.接受高效抗逆转录病毒治疗（HAART）失败的HIV-1感染患者中CD4阳性T细胞计数的不一致变化

Jpn J Infect Dis. 2002 Apr;55(2):62-5.

Utility of repeat genotypic resistance testing and clinical response in patients with three class resistance and virologic treatment failure.三类耐药且病毒学治疗失败患者重复基因型耐药检测的效用及临床反应

AIDS Patient Care STDS. 2007 Aug;21(8):544-50. doi: 10.1089/apc.2006.0156.

Human immunodeficiency virus type 1 (HIV-1) genotyping in Rio de Janeiro, Brazil: assessing subtype and drug-resistance associated mutations in HIV-1 infected individuals failing highly active antiretroviral therapy.巴西里约热内卢的1型人类免疫缺陷病毒（HIV-1）基因分型：评估接受高效抗逆转录病毒治疗失败的HIV-1感染者的亚型和耐药相关突变。

Mem Inst Oswaldo Cruz. 2005 Feb;100(1):73-8. doi: 10.1590/s0074-02762005000100014. Epub 2005 Apr 12.

Drug resistance mutations and outcome of second-line treatment in patients with first-line protease inhibitor failure on nelfinavir-containing HAART.含奈非那韦的高效抗逆转录病毒治疗中一线蛋白酶抑制剂治疗失败患者的耐药突变及二线治疗结果

HIV Med. 2003 Jan;4(1):38-47. doi: 10.1046/j.1468-1293.2003.00133.x.

Transmission of HIV-1 minority-resistant variants and response to first-line antiretroviral therapy.HIV-1 少数耐药变异株的传播及对一线抗逆转录病毒治疗的反应

AIDS. 2008 Jul 31;22(12):1417-23. doi: 10.1097/QAD.0b013e3283034953.

Analysis of HIV- type 1 protease and reverse transcriptase in Brazilian children failing highly active antiretroviral therapy (HAART).对巴西接受高效抗逆转录病毒疗法（HAART）治疗失败的儿童的1型HIV蛋白酶和逆转录酶的分析。

Rev Inst Med Trop Sao Paulo. 2005 Jan-Feb;47(1):1-5. doi: 10.1590/s0036-46652005000100001. Epub 2005 Feb 23.

引用本文的文献

Characterization of two HIV-1 infectors during initial antiretroviral treatment, and the emergence of phenotypic resistance in reverse transcriptase-associated mutation patterns.初始抗逆转录病毒治疗期间两种HIV-1感染源的特征分析以及逆转录酶相关突变模式中表型耐药性的出现。

Virol J. 2015 Nov 14;12:187. doi: 10.1186/s12985-015-0417-y.

Significant reductions in Gag-protease-mediated HIV-1 replication capacity during the course of the epidemic in Japan.在日本的疫情发展过程中，Gag-protease 介导的 HIV-1 复制能力显著降低。

J Virol. 2013 Feb;87(3):1465-76. doi: 10.1128/JVI.02122-12. Epub 2012 Nov 14.

Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy.临床、病毒学和生物化学证据支持 HIV-1 逆转录酶多态性 R284K 与替诺福韦/恩曲他滨治疗失败患者中胸苷类似物耐药突变 M41L、L210W 和 T215Y 的关联。

Retrovirology. 2012 Aug 13;9:68. doi: 10.1186/1742-4690-9-68.

Select resistance-associated mutations in blood are associated with lower CSF viral loads and better neuropsychological performance.血液中与选择耐药相关的突变与较低的脑脊液病毒载量及较好的神经心理学表现相关。

Virology. 2009 Nov 25;394(2):243-8. doi: 10.1016/j.virol.2009.08.007. Epub 2009 Sep 16.

Virologic and immunologic response to highly active antiretroviral therapy.高效抗逆转录病毒治疗的病毒学和免疫学反应

Curr HIV/AIDS Rep. 2004 Jun;1(2):74-81. doi: 10.1007/s11904-004-0011-1.

Update on the Virologic and Immunologic Response to Highly Active Antiretroviral Therapy.高效抗逆转录病毒疗法的病毒学和免疫学反应最新进展

Curr Infect Dis Rep. 2004 Aug;6(4):325-332. doi: 10.1007/s11908-004-0055-9.

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Drug-resistant mutants of HIV-1 in patients exhibiting increasing CD4 cell count despite virological failure of highly active antiretroviral therapy.

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