对于卵巢激素储备测试正常的39岁以上女性，可用于移植的胚胎数量可预测妊娠成功结局。
The number of embryos available for transfer predicts successful pregnancy outcome in women over 39 years with normal ovarian hormonal reserve testing.
作者信息
Opsahl M S, Blauer K L, Black S H, Lincoln S R, Thorsell L, Sherins R J
机构信息
Genetics & IVF Institute, 3020 Javier Road, Fairfax, Virginia 22031, USA.
出版信息
J Assist Reprod Genet. 2001 Oct;18(10):551-6. doi: 10.1023/a:1011906024170.
Abstract
PURPOSE
The purpose was to determine whether the number of embryos available for transfer following IVF in women over age 39 predicted a successful pregnancy outcome.
METHODS
Retrospective analysis of 455 consecutive IVF cycles in women > or = 40 years of age.
RESULTS
Few cycles were canceled (29/455, 6.4%) or produced no embryos (5/455, 1.1%). Women 40-43 years of age with normal ovarian reserve had a significantly greater delivery rate when > or = 4 embryos were available for transfer than when < 4 embryos were available (17.8% versus 2.4%, P = 0.002). Subsequent IVF cycles, from women with normal FSH whose first cycle produced < 4 embryos, produced delivery rates of 13.0% when > or = 4 embryos were available. Women with abnormal ovarian reserve or age > or = 44 years had very low delivery rates (1.2% and 1.4% respectively).
CONCLUSIONS
The number of embryos available for transfer significantly predicts delivery from IVF-ET among reproductively older women. Many women age 40-43 with normal ovarian reserve can achieve pregnancy through IVF.
摘要
目的
本研究旨在确定39岁以上女性体外受精（IVF）后可用于移植的胚胎数量是否能预测妊娠成功结局。
方法
对455例年龄大于或等于40岁女性的连续IVF周期进行回顾性分析。
结果
很少有周期被取消（29/455，6.4%）或未产生胚胎（5/455，1.1%）。卵巢储备功能正常的40 - 43岁女性，当有大于或等于4个胚胎可用于移植时，其分娩率显著高于可用于移植的胚胎小于4个时（17.8%对2.4%，P = 0.002）。对于促卵泡生成素（FSH）正常且首个周期产生的胚胎小于4个的女性，随后的IVF周期中，当有大于或等于4个胚胎可用于移植时，分娩率为13.0%。卵巢储备功能异常或年龄大于或等于44岁的女性分娩率非常低（分别为1.2%和1.4%）。
结论
可用于移植的胚胎数量能显著预测高龄女性IVF - ET后的分娩情况。许多卵巢储备功能正常的40 - 43岁女性可通过IVF实现妊娠。
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本文引用的文献
1
Infertile women of advanced reproductive age. Variability of day 3 FSH and E2 levels.
J Reprod Med. 1998 Dec;43(12):1023-6.
2
Assessment of the role of serum luteinizing hormone and estradiol response to follicle-stimulating hormone on in vitro fertilization treatment outcome.评估血清促黄体生成素和雌二醇对促卵泡激素反应在体外受精治疗结局中的作用。
Fertil Steril. 1997 May;67(5):889-99. doi: 10.1016/s0015-0282(97)81402-1.
3
The ovarian response as a predictor for successful in vitro fertilization treatment after the age of 40 years.40岁以后，卵巢反应作为体外受精治疗成功的预测指标。
Fertil Steril. 1996 Dec;66(6):969-73. doi: 10.1016/s0015-0282(16)58691-9.
4
Reproductive aging: accelerated ovarian follicular development associated with a monotropic follicle-stimulating hormone rise in normal older women.生殖衰老：正常老年女性中与促卵泡激素单峰升高相关的卵巢卵泡发育加速。
J Clin Endocrinol Metab. 1996 Mar;81(3):1038-45. doi: 10.1210/jcem.81.3.8772573.
5
Future in vitro fertilization pregnancy potential of women with variably elevated day 3 follicle-stimulating hormone levels.第3天促卵泡激素水平呈不同程度升高的女性未来体外受精的妊娠潜力
Fertil Steril. 1996 Jun;65(6):1238-40. doi: 10.1016/s0015-0282(16)58347-2.
6
Life table analysis of pregnancy rates in a general infertility population relative to ovarian reserve and patient age.普通不孕人群中妊娠率相对于卵巢储备和患者年龄的生命表分析。
Hum Reprod. 1995 Jul;10(7):1706-10. doi: 10.1093/oxfordjournals.humrep.a136159.
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Variability of day 3 follicle-stimulating hormone levels in eumenorrheic women.月经周期正常女性第3天促卵泡生成素水平的变异性
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8
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Fertil Steril. 1996 Jan;65(1):103-8. doi: 10.1016/s0015-0282(16)58035-2.
9
A prospective evaluation of clomiphene citrate challenge test screening of the general infertility population.枸橼酸氯米芬激发试验对一般不孕人群筛查的前瞻性评估。
Obstet Gynecol. 1993 Oct;82(4 Pt 1):539-44.
10
Perimenopausal patterns of gonadotrophins, immunoreactive inhibin, oestradiol and progesterone.围绝经期促性腺激素、免疫反应性抑制素、雌二醇和孕酮的变化模式
Maturitas. 1993 Dec;18(1):9-20. doi: 10.1016/0378-5122(93)90026-e.
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