Federspil P A, Constantinidis J, Karapantzos I, Pahl S, Markmann H U, Iro H
Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, Universitätskliniken des Saarlandes, Kirrberger Strasse, 66421 Homburg, Saar.
HNO. 2001 Oct;49(10):825-30. doi: 10.1007/s001060170031.
Acinic cell carcinoma of the parotid gland is a rare malignant tumor, which is generally regarded as low grade. However, rapidly fatal courses do occur.
Eighteen patients with acinic cell carcinoma were studied retrospectively who had undergone treatment between 1968 and 1997 at the University Ear, Nose, and Throat (ENT) Hospital in Homburg (Saar), Germany and between 1994 and 1997 at the Marienhospital ENT Hospital in Stuttgart, Germany.
The distribution of the T category (UICC 1997) was as follows: T1 n = 8, T2 n = 7, T3 n = 1, and T4 n = 2). Treatment was exclusively surgical in 14 cases and a combination of surgery and postoperative radiotherapy in 4 cases. The recurrence rate according to Kaplan-Meier was 6% after 3 years and 19% after 5, 10, and 15 years. The survival rate was 87% after 3 years and 73% after 5, 10, and 15 years. None of the 12 patients with low-grade tumors according to Batsakis et al. (1979) died from the tumor, whereas survival at 5 years was only 33% for 6 high-grade tumors (p = 0.02).
We recommend complete surgical removal of the tumor, in general by total parotidectomy. Postoperative radiotherapy may be useful in advanced high-grade tumors.
腮腺腺泡细胞癌是一种罕见的恶性肿瘤，通常被认为是低级别肿瘤。然而，确实会出现迅速致命的病程。
回顾性研究了18例腮腺腺泡细胞癌患者，这些患者于1968年至1997年在德国洪堡（萨尔）大学耳鼻喉科医院以及1994年至1997年在德国斯图加特玛丽恩医院耳鼻喉科医院接受了治疗。
T分期（UICC 1997）分布如下：T1期n = 8，T2期n = 7，T3期n = 1，T4期n = 2。14例患者仅接受了手术治疗，4例患者接受了手术与术后放疗联合治疗。根据Kaplan-Meier法，3年后复发率为6%，5年、10年和15年后复发率为19%。3年后生存率为87%，5年、10年和15年后生存率为73%。根据Batsakis等人（1979年）的标准，12例低级别肿瘤患者中无一例死于该肿瘤，而6例高级别肿瘤患者的5年生存率仅为33%（p = 0.02）。
我们建议一般通过全腮腺切除术完整地手术切除肿瘤。术后放疗可能对晚期高级别肿瘤有用。
