Magnano M, gervasio C F, Cravero L, Machetta G, Lerda W, Beltramo G, Orecchia R, Ragona R, Bussi M
Department of Clinical Physiopathology, Second ENT Clinic, University of Turin.
Otolaryngol Head Neck Surg. 1999 Nov;121(5):627-32. doi: 10.1016/S0194-5998(99)70070-7.
In this study we evaluated the effects of surgical and radiotherapy treatment on local control in 126 patients with malignant tumors of the parotid gland. The most frequently observed malignant tumors were high-grade tumors (68%). Surgical treatment was performed in 81 patients (83.5%). Total conservative parotidectomy was the most frequent procedure (74%), and radiotherapy was performed in 81 patients (83.5%). The global survival rate was approximately 54% at 5 years, whereas disease-free survival was 47% at 5 years. No statistically significant difference in survival rate was found between conservative (52% at 5 years) and radical treatment of the seventh cranial nerve (43% at 5 years). The incidence of recurrent cancer was 25.7% (25 of 97), of which 88% developed during the first 2 years. We report some of the clinical and histologic factors that can influence the prognosis of the disease.
在本研究中，我们评估了手术和放射治疗对126例腮腺恶性肿瘤患者局部控制的影响。最常观察到的恶性肿瘤是高级别肿瘤（68%）。81例患者（83.5%）接受了手术治疗。全腮腺保留切除术是最常见的手术方式（74%），81例患者（83.5%）接受了放射治疗。5年时总体生存率约为54%，而无病生存率为47%。保守治疗（5年时为52%）和第七颅神经根治性治疗（5年时为43%）之间的生存率无统计学显著差异。复发性癌症的发生率为25.7%（97例中的25例），其中88%在头两年内发生。我们报告了一些可能影响该疾病预后的临床和组织学因素。
