Riedel F, Back W, Götte K, Hörmann K
Universitäts-Hals-Nasen-Ohren-Klinik, Klinikum Mannheim.
HNO. 2001 Oct;49(10):837-41. doi: 10.1007/s001060170033.
Follicular dendritic cells (FDC) constitute an essential component of B cell follicles, normally serving as antigen-presenting cells and as cells regulating the germinal center reaction. FDC sarcoma is a very rare tumor. We report the case of a 55-year-old male patient who showed persistent cervical lymph node swelling. On biopsy the tumor consisted of spindle cells with nuclear atypia. Immunophenotypic investigation of the tumor tissue revealed a FDC sarcoma of a cervical lymph node. The tumor cells were characterized immunohistochemically especially by the expression of CD21 and focal expression of CD68. In conclusion, FDC sarcoma has to be considered in cases of tumors of uncertain origin in cervical lymph nodes, tonsils, soft palate, or nasopharynx. For clinical practice, it is important to note that sarcomas in cervical lymph nodes are not necessarily metastases but can be primary tumors.
滤泡树突状细胞（FDC）是B细胞滤泡的重要组成部分，通常作为抗原呈递细胞和调节生发中心反应的细胞。FDC肉瘤是一种非常罕见的肿瘤。我们报告一例55岁男性患者，表现为持续性颈部淋巴结肿大。活检显示肿瘤由具有核异型性的梭形细胞组成。对肿瘤组织进行免疫表型研究，结果显示为颈部淋巴结FDC肉瘤。肿瘤细胞的免疫组化特征尤其表现为CD21表达及CD68局灶性表达。总之，对于起源不明的颈部淋巴结、扁桃体、软腭或鼻咽部肿瘤病例，必须考虑FDC肉瘤。对于临床实践而言，需要注意的是，颈部淋巴结肉瘤不一定是转移瘤，也可能是原发性肿瘤。
