Khalid Safoorah, Yaqoob Nausheen, Pervez Shahid
Department of Pathology and Microbiology, The Aga Khan University, Karachi.
J Pak Med Assoc. 2006 Mar;56(3):137-9.
Follicular dendritic cells (FDC) are non-lymphoid, non-phagocytic accessory cells in the immune system that are essential for antigen presentation and germinal center reaction regulation. These cells are CD21+, CD35+, CD1a- and S100 protein +/- and they show desmosomes ultrastructurally. The most commonly involved sites by FDC tumors are lymph nodes but may arise at a variety of extranodal sites including oral cavity, tonsil, gastrointestinal tract and liver. Most studies represent single case reports or case series. Our patient presented with tumor in the lymph nodes. Histology revealed tumor cells with abundant eosinophilic cytoplasm, hyperchromatic and pleomorphic nuclei, and prominent nucleoli. The tumor cells were found to be positive for CD21 which is a specific marker for follicular dendritic cells.
滤泡树突状细胞（FDC）是免疫系统中的非淋巴细胞、非吞噬性辅助细胞，对抗抗原呈递和生发中心反应调节至关重要。这些细胞CD21阳性、CD35阳性、CD1a阴性且S100蛋白弱阳性，超微结构显示有桥粒。FDC肿瘤最常累及的部位是淋巴结，但也可能出现在包括口腔、扁桃体、胃肠道和肝脏在内的各种结外部位。大多数研究为单病例报告或病例系列。我们的患者表现为淋巴结肿瘤。组织学检查显示肿瘤细胞具有丰富的嗜酸性细胞质、核深染且多形性，核仁突出。发现肿瘤细胞CD21阳性，CD21是滤泡树突状细胞的特异性标志物。
