Kimura S, Kuroda J, Akaogi T, Hayashi H, Kobayashi Y, Kondo M
Division of Hematology, Kyoto Second Red Cross Hospital, 355-5 Haruobi Kamigyo-ku, First Department of Internal Medicine, Kyoto Prefectural University of Medicine, 465 Kajii Kamigyo-ku, Kyoto, Japan.
Leuk Lymphoma. 2001 Jun;42(1-2):115-21. doi: 10.3109/10428190109097683.
Only 12 myelodysplastic syndrome (MDS) cases with Behçet's syndrome have been previously reported and trisomy 8 was found to have accumulated in all these patients. Five of the cases had complications in the form of multiple intestinal ulcers, which is one of the symptoms of Behçet's syndrome. To investigate the relationship between trisomy 8 and multiple intestinal ulcers in MDS patients, we analyzed 46 MDS cases treated in our hospital over the last decade, and trisomy 8 was observed in eight of them. Three of these cases had complications of both multiple intestinal ulcers and thrombosis, and two cases showed episodes of thrombosis without intestinal ulcers. All these five cases featured trisomy 8, while the other 38 MDS patients without trisomy 8 had no episode of either intestinal ulcer or thrombosis. Two of the three cases suffering from multiple intestinal ulcers were treated with granulocyte-colony stimulating factor (G-CSF), which resulted in aggravation of the symptoms. Although the influence of G-CSF on such symptoms in MDS patients with trisomy 8 remains unclear, it seems advisable to exercise caution in the use of G-CSF when an MDS patient with trisomy 8 has intestinal ulcers or thrombosis.
此前仅报道过12例患有白塞病的骨髓增生异常综合征（MDS）病例，且发现所有这些患者均存在8号染色体三体。其中5例出现了多发性肠道溃疡形式的并发症，这是白塞病的症状之一。为了研究MDS患者中8号染色体三体与多发性肠道溃疡之间的关系，我们分析了我院过去十年间治疗的46例MDS病例，其中8例观察到8号染色体三体。这些病例中有3例同时出现了多发性肠道溃疡和血栓形成的并发症，2例仅表现为血栓形成而无肠道溃疡。所有这5例均有8号染色体三体，而其他38例无8号染色体三体的MDS患者既没有肠道溃疡发作也没有血栓形成。3例患有多发性肠道溃疡的患者中有2例接受了粒细胞集落刺激因子（G-CSF）治疗，结果症状加重。虽然G-CSF对8号染色体三体的MDS患者此类症状的影响尚不清楚，但当8号染色体三体的MDS患者出现肠道溃疡或血栓形成时，使用G-CSF时似乎应谨慎。
