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[机械性创伤后复发性角膜糜烂。经上皮光疗性角膜切削术的结果]

[Recurrent corneal erosion after mechanical trauma. Results of transepithelial phototherapeutic keratectomy].

作者信息

Giessler S, Duncker G I

机构信息

Klinik und Poliklinik für Augenheilkunde, Martin Luther Universität Halle-Wittenberg.

出版信息

Ophthalmologe. 2001 Oct;98(10):950-4. doi: 10.1007/s003470170042.

Abstract

BACKGROUND

Recurrent corneal erosion is a common clinical disorder characterised by repeated spontaneous breakdown of the corneal epithelium. The pathomechanism is due to abnormalities of the adhesion complex between the corneal epithelium and the stroma. In addition to local medical treatment, bandage lenses, debridement and anterior stromal puncture, patients can also be treated by excimer laser phototherapeutic keratectomy.

METHODS

We present a series of 45 eyes where a transepithelial therapeutic excimer photoablation (t-PTK) was carried out after recurrent erosions caused by mechanical trauma. We used the flying spot excimer laser Technolas 217-C (Bausch & Lomb Surgical) and the scanning spot laser MEL70 (Aesculap Meditec). Treatment was performed in the relapse-free period. The zone of ablation measured 6-9 mm and the ablation depth 10-30 microns. The mean follow-up period was 7 months (range 3-22).

RESULTS

After the first t-PTK treatment, 41 eyes remained without a relapse, but 8 patients had persistent symptoms, 4 of which had a new epithelial breakdown and in 2 patients a second t-PTK had to be carried out.

CONCLUSIONS

T-PTK appears to be a safe and effective procedure for treatment of recurrent corneal erosion. However, relative contraindications, such as a previous chemical burn, must be taken into account.

摘要

背景

复发性角膜糜烂是一种常见的临床病症,其特征为角膜上皮反复自发破裂。发病机制是由于角膜上皮与基质之间的黏附复合体异常。除了局部药物治疗、绷带镜、清创术和前基质穿刺外,患者还可通过准分子激光角膜切削术进行治疗。

方法

我们呈现了一系列45只眼睛,这些眼睛在机械性创伤导致复发性糜烂后接受了经上皮准分子激光治疗性光消融(t-PTK)。我们使用了飞点准分子激光Technolas 217-C(博士伦外科公司)和扫描点激光MEL70(蛇牌美迪克公司)。治疗在无复发期进行。消融区域为6 - 9毫米,消融深度为10 - 30微米。平均随访期为7个月(范围3 - 22个月)。

结果

首次t-PTK治疗后,41只眼睛未复发,但8名患者仍有持续症状,其中4名出现新的上皮破裂,2名患者不得不接受第二次t-PTK治疗。

结论

t-PTK似乎是治疗复发性角膜糜烂的一种安全有效的方法。然而,必须考虑相对禁忌证,如既往化学烧伤。

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