Pancharoen C, Mekmullica J, Chinratanapisit S, Bhattarakosol P, Thisyakorn U
Department of Pediatrics, Chulalongkorn Hospital, Bangkok, Thailand.
Asian Pac J Allergy Immunol. 2001 Jun;19(2):135-7.
There are no current data on previous Epstein-Barr virus (EBV) infections in different age groups of Thai children. This study was conducted to determine the prevalence of anti-EBV IgG antibody in healthy children of various age ranges in Bangkok, Thailand. Between June and December 1998, blood samples were collected from 425 volunteers aged 6 months to 15 years who attended a well baby clinic in the northern suburban part of Bangkok, Thailand. Serum samples were assayed for specific anti-EBV IgG antibodies using a commercial enzyme-linked immunosorbent assay kit. The percentage of children with positive anti-EBV IgG antibody increased with advancing age. The overall seropositivity rate was 72.7%. Children with anti-EBV IgG antibody were significantly older than those without the antibody. Seronegative children were reared at home significantly more frequently than seropositive children. These seroopidemiologic data will guide calculation of the appropriate age for administration of an EBV vaccine to children, when it becomes available.
目前尚无关于泰国儿童不同年龄组既往感染爱泼斯坦-巴尔病毒（EBV）的相关数据。本研究旨在确定泰国曼谷不同年龄范围健康儿童中抗EBV IgG抗体的流行情况。1998年6月至12月期间，从泰国曼谷北郊一家健康婴儿诊所的425名6个月至15岁的志愿者中采集血样。使用商用酶联免疫吸附测定试剂盒检测血清样本中特异性抗EBV IgG抗体。抗EBV IgG抗体阳性儿童的比例随年龄增长而增加。总体血清阳性率为72.7%。有抗EBV IgG抗体的儿童明显比没有该抗体的儿童年龄大。血清阴性儿童在家抚养的频率明显高于血清阳性儿童。这些血清流行病学数据将指导在EBV疫苗可供儿童使用时，计算适合接种疫苗的年龄。
