富肌林（一种用于直接压片的新型改性无水磷酸氢钙）的特性：与二水磷酸氢钙的比较。

Properties of fujicalin, a new modified anhydrous dibasic calcium phosphate for direct compression: comparison with dicalcium phosphate dihydrate.

作者信息

Schlack H, Bauer-Brandl A, Schubert R, Becker D

机构信息

Universität Freiburg, Pharmazeutische Technologie, Germany.

出版信息

Drug Dev Ind Pharm. 2001 Sep;27(8):789-801. doi: 10.1081/ddc-100107242.

DOI:10.1081/ddc-100107242

PMID:11699830

Abstract

The novel, commercially available, free-flowing spherically granulated dicalcium phosphate anhydrous (SGDCPA) Fujicalin for direct tableting was compared with directly compressible dicalcium phosphate dihYdrate (DCPD), the properties of which are well known. The two excipients were investigated and compared with regard to their physical and powder properties, compressibility, and compactibility. As a consequence of the spherical shape of its particles, SGDCPA shows the same good flowability and even better compactibility. In contrast to DCPD, SGDCPA shows significant uptake of moisture when exposed to relative humidities (RHs) exceeding 70%. For both excipients, the main deformation mechanism is fragmentation, with SGDCPA yielding significantly stronger tablets.

摘要

将新型的、市售的、用于直接压片的自由流动球形颗粒无水磷酸二钙（SGDCPA）“富士钙”与直接压片用的二水磷酸二钙（DCPD）进行比较，后者的性能是众所周知的。对这两种辅料的物理和粉末特性、可压性和成型性进行了研究和比较。由于其颗粒呈球形，SGDCPA表现出同样良好的流动性，甚至具有更好的成型性。与DCPD不同，当暴露于相对湿度（RH）超过70%的环境中时，SGDCPA会大量吸湿。对于这两种辅料，主要的变形机制都是破碎，SGDCPA制成的片剂强度明显更高。