Faulkner G, Lanfranchi G, Valle G
International Centre for Genetic Engineering and Biotechnology, Padriciano, Trieste, Italy.
IUBMB Life. 2001 May;51(5):275-82. doi: 10.1080/152165401317190761.
This brief review outlines some of the most relevant proteins of the Z-disc and the complex network of interactions that link them together in a stable structure. Apart from the well-known Z-disc proteins such as actin, cap-Z, titin, nebulin, and alpha-actinin 2, several other Z-disc proteins have been recently discovered, including telethonin and myotilin that have been linked to limb girdle muscular dystrophies. Some proteins including ALP and ZASP have known interaction domains (PDZ and LIM motifs), whereas others like FATZ have no canonical interaction domains, although they are known to bind several proteins. Another new Z-disc protein is gamma-filamin that could provide a link between the plasma membrane and myofibrils because it binds directly to gamma- and delta-sarcoglycans and indirectly to alpha-actinin 2 via FATZ and myotilin. A greater knowledge of Z-disc proteins and their interactions is essential for understanding their role in the structure and function of muscle.
本简要综述概述了一些与Z盘最相关的蛋白质以及将它们连接成稳定结构的复杂相互作用网络。除了众所周知的Z盘蛋白，如肌动蛋白、帽Z、肌联蛋白、伴肌动蛋白和α-辅肌动蛋白2外，最近还发现了其他几种Z盘蛋白，包括与肢带型肌营养不良相关的隐窝蛋白和肌联蛋白。一些蛋白质，如碱性磷酸酶（ALP）和ZASP，具有已知的相互作用结构域（PDZ和LIM基序），而其他蛋白质，如FATZ，没有典型的相互作用结构域，尽管已知它们能结合多种蛋白质。另一种新的Z盘蛋白是γ-细丝蛋白，它可以在质膜和肌原纤维之间提供联系，因为它直接结合γ-和δ-肌聚糖，并通过FATZ和肌联蛋白间接结合α-辅肌动蛋白2。深入了解Z盘蛋白及其相互作用对于理解它们在肌肉结构和功能中的作用至关重要。
