Sonnenfeld N, Hertz-Picciotto I, Kaye W E
Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, GA, USA.
Am J Epidemiol. 2001 Nov 15;154(10):902-8. doi: 10.1093/aje/154.10.902.
A study of mean birth weight, small-for-gestational-age infants, and preterm birth was conducted at the US Marine Corps Base at Camp Lejeune, North Carolina, where drinking water was contaminated with volatile organic compounds. Tetrachloroethylene (PCE) was the predominant contaminant. The authors used multiple linear and logistic regression to analyze 1968-1985 data from 11,798 birth certificates. Overall, at most weak associations were observed between PCE exposure and study outcomes. However, associations were found between PCE exposure and birth-weight outcomes for infants of older mothers and mothers with histories of fetal loss. Adjusted mean birth-weight differences between PCE-exposed and unexposed infants were -130 g (90% confidence interval (CI): -236, -23) for mothers aged 35 years or older and -104 g (90% CI: -174, -34) for mothers with two or more previous fetal losses. Adjusted odds ratios for PCE exposure and small-for-gestational-age infants were 2.1 (90% CI: 0.9, 4.9) for older mothers and 2.5 (90% CI: 1.5, 4.3) for mothers with two or more prior fetal losses. These results suggest that some fetuses may be more vulnerable than others to chemical insult.
在北卡罗来纳州勒琼营的美国海军陆战队基地进行了一项关于平均出生体重、小于胎龄儿和早产的研究，该基地的饮用水被挥发性有机化合物污染。四氯乙烯（PCE）是主要污染物。作者使用多元线性回归和逻辑回归分析了1968年至1985年11798份出生证明的数据。总体而言，在PCE暴露与研究结果之间最多观察到微弱的关联。然而，在年龄较大的母亲和有胎儿丢失史的母亲的婴儿中，发现了PCE暴露与出生体重结果之间的关联。对于35岁及以上的母亲，暴露于PCE和未暴露于PCE的婴儿之间调整后的平均出生体重差异为-130克（90%置信区间（CI）：-236，-23）；对于有两次或更多次先前胎儿丢失的母亲，差异为-104克（90%CI：-174，-34）。对于年龄较大的母亲，PCE暴露与小于胎龄儿的调整后比值比为2.1（90%CI：0.9，4.9）；对于有两次或更多次先前胎儿丢失的母亲，比值比为2.5（90%CI：1.5，4.3）。这些结果表明，一些胎儿可能比其他胎儿更容易受到化学损伤。
