Fewell S W, Travers K J, Weissman J S, Brodsky J L
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Annu Rev Genet. 2001;35:149-91. doi: 10.1146/annurev.genet.35.102401.090313.
The endoplasmic reticulum (ER) serves as a way-station during the biogenesis of nearly all secreted proteins, and associated with or housed within the ER are factors required to catalyze their import into the ER and facilitate their folding. To ensure that only properly folded proteins are secreted and to temper the effects of cellular stress, the ER can target aberrant proteins for degradation and/or adapt to the accumulation of misfolded proteins. Molecular chaperones play critical roles in each of these phenomena.
内质网（ER）在几乎所有分泌蛋白的生物合成过程中充当一个中转站，并且与催化蛋白质导入内质网以及促进其折叠所需的因子相关联或存在于内质网内。为确保只有正确折叠的蛋白质才能被分泌，并缓和细胞应激的影响，内质网可以将异常蛋白质靶向降解和/或适应错误折叠蛋白质的积累。分子伴侣在这些现象中均发挥着关键作用。
