Hammond C, Helenius A
Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06511, USA.
Curr Opin Cell Biol. 1995 Aug;7(4):523-9. doi: 10.1016/0955-0674(95)80009-3.
Whereas newly synthesized proteins that have acquired a properly folded and assembled structure are transported from the endoplasmic reticulum to their final destinations, incompletely folded and assembled proteins are, as a rule, retained and eventually degraded. The molecular mechanisms of this unique molecular sorting phenomenon, called 'quality control', have been illuminated by recent studies.
新合成的蛋白质若已获得正确折叠和组装的结构，便会从内质网转运至其最终目的地，而未完全折叠和组装的蛋白质通常会被滞留并最终降解。这种被称为“质量控制”的独特分子分选现象的分子机制，已被近期的研究所阐明。
