Nicolson P C, Vogt J
Lens Business Unit Research and Development, CIBA Vision Corporation, Duluth, Georgia 30097-1556, USA.
Biomaterials. 2001 Dec;22(24):3273-83. doi: 10.1016/s0142-9612(01)00165-x.
A review of patents and literature reveals an evolution in materials technologies. The evolution has been driven by an increased understanding of the physiological needs of the cornea, beginning with the first hydrogel lenses developed by Wichterle, followed by a variety of high water hydrogels. Oxygen transmission requirements have been addressed through the use of siloxane and fluorosiloxane containing hydrogels. An important development has been the appreciation of the importance of polymer phase morphology on lens movement on the eye. In parallel with these activities have come the advancements in materials suitable to high volume, low cost production necessary for today's daily disposable lenses.
对专利和文献的回顾揭示了材料技术的演变。这种演变是由对角膜生理需求的深入理解推动的,从Wichterle开发的第一代水凝胶镜片开始,随后出现了各种高含水量水凝胶。通过使用含硅氧烷和氟硅氧烷的水凝胶解决了氧气传输要求。一个重要的进展是认识到聚合物相形态对镜片在眼睛上移动的重要性。与这些活动同时出现的是适合当今日抛型镜片所需的大批量、低成本生产的材料的进步。