Apostolides Demetris E, Michael George, Patrickios Costas S, Sakai Takamasa, Kyroglou Iro, Kasimatis Maria, Iatrou Hermis, Prévost Sylvain, Gradzielski Michael
Department of Chemistry, University of Cyprus, P.O. Box 20537, Nicosia 1678, Cyprus.
Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Gels. 2025 Apr 29;11(5):331. doi: 10.3390/gels11050331.
Herein we describe the development of the first amphiphilic polymer conetwork (APCN) comprising a short hydrophobic hexa(-alanine) segment being the outer block of an amphiphilic four-armed star block copolymer with inner poly(ethylene glycol) (PEG) blocks bearing benzaldehyde terminal groups and end-linked with another four-armed star PEG homopolymer (tetraPEG star) bearing aryl-substituted acylhydrazide terminal groups. The present successful synthesis that yielded the peptide-containing model APCN was preceded by several unsuccessful efforts that followed different synthetic strategies. In addition to the synthetic work, we also present the structural characterization of the peptide-bearing APCN in DO using small-angle neutron scattering (SANS).
在此，我们描述了首个两亲性聚合物共网络（APCN）的开发，该共网络包含一个短的疏水性六（丙氨酸）片段，它是两亲性四臂星形嵌段共聚物的外层嵌段，其内层为带有苯甲醛端基的聚乙二醇（PEG）嵌段，并与另一个带有芳基取代酰肼端基的四臂星形PEG均聚物（四臂PEG星形聚合物）进行端基连接。在目前成功合成含肽模型APCN之前，曾采用不同的合成策略进行了几次不成功的尝试。除了合成工作外，我们还利用小角中子散射（SANS）对溶解在氘代溶剂（DO）中的含肽APCN进行了结构表征。
