带有多孔裙边的人工角膜的发展概况以及聚甲基丙烯酸羟乙酯在该应用中的使用。
An overview of the development of artificial corneas with porous skirts and the use of PHEMA for such an application.
作者信息
Chirila T V
机构信息
Centre for Ophthalmology and Visual Science and Lions Eye Institute, University of Western Australia, Nedlands, Australia.
出版信息
Biomaterials. 2001 Dec;22(24):3311-7. doi: 10.1016/s0142-9612(01)00168-5.
An overview of the efforts to develop functional polymeric artificial corneas (keratoprostheses) by incorporating a porous skirt is presented. The development of such a device by the author's group using poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels, as a combination of their homogeneous and heterogeneous states, and the rationale of this choice are also discussed. The latest results of the clinical trials with the PHEMA keratoprosthesis in human patients indicate a lower risk of the complications traditionally associated with the implantation of artificial corneas.
本文概述了通过结合多孔裙边来开发功能性聚合物人工角膜（角膜假体）的相关工作。作者团队利用聚甲基丙烯酸2-羟乙酯（PHEMA）水凝胶，结合其均相和非均相状态来开发这种装置，并讨论了做出这种选择的理由。PHEMA角膜假体在人类患者中的最新临床试验结果表明，与传统人工角膜植入相关的并发症风险较低。
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