Stadler J R, Caul W F, Barrett R J
Department of Psychology, Vanderbilt University, 301 Wilson Hall, Nashville, TN 37203, USA.
Pharmacol Biochem Behav. 2001 Oct-Nov;70(2-3):381-6. doi: 10.1016/s0091-3057(01)00616-5.
Rats were trained to discriminate one of three doses of amphetamine (AM), 0.5, 1, or 2 mg/kg, from vehicle (VEH) in a two-lever, food-reinforced, drug-discrimination task. The purpose of the study was to investigate the nature of the shift of the dose-response curve and generalization to cocaine (COC) as a function of training dose. In order to preclude potential differences among the groups in stimulus control, the three training-dose groups were required to perform the discrimination at high and equivalent levels of accuracy. The shift of the dose-response functions to the right as a function of increasing training dose was not parallel. The slope decreased as training dose increased. There was a dose-dependent increase in AM lever responding to test doses of COC that tended to be affected by training dose. The results suggest that proper evaluation of training-dose effects requires that groups be trained to equivalent levels of stimulus control.
在一项双杠杆、食物强化的药物辨别任务中，训练大鼠从赋形剂（VEH）中辨别三种剂量（0.5、1或2mg/kg）的苯丙胺（AM）中的一种。本研究的目的是调查剂量反应曲线的变化性质以及作为训练剂量函数的对可卡因（COC）的泛化情况。为了排除各组在刺激控制方面的潜在差异，要求三个训练剂量组以高且相当的准确度进行辨别。剂量反应函数随训练剂量增加向右的移动并不平行。斜率随着训练剂量增加而减小。对COC测试剂量的AM杠杆反应存在剂量依赖性增加，这倾向于受训练剂量影响。结果表明，对训练剂量效应的恰当评估要求将各组训练至相当的刺激控制水平。
