Vogel W F
Laboratory of Extracellular Matrix Signaling and Tumor Invasion, Georg-Speyer-Haus, Institute for Biomedical Research, affiliated with the Johann Wolfgang Goethe-University Frankfurt, 60596 Frankfurt am Main, Germany.
Eur J Dermatol. 2001 Nov-Dec;11(6):506-14.
Collagens are not only essential for the mechanical resistance and resilience of multicellular organisms, but are also signaling molecules defining cellular shape and behavior. The communication between collagens and cells is achieved by cell surface receptors. Three types of cell surface receptors for collagen are known: integrins, discoidin domain receptors and glycoprotein VI. All three types independently trigger a variety of signaling pathways upon collagen-binding. Besides regulating numerous cellular responses, both integrin and discoidin domain receptors monitor the integrity of the collagenous extracellular matrix by triggering matrix degradation and renewal. Some recently discovered mechanisms of locally controlled expression of collagen, collagen-binding receptors and collagen-degrading proteases in the cellular microenvironment are described.
胶原蛋白不仅对于多细胞生物的机械抗性和弹性至关重要，而且还是定义细胞形状和行为的信号分子。胶原蛋白与细胞之间的通讯是通过细胞表面受体实现的。已知三种类型的胶原蛋白细胞表面受体：整合素、盘状结构域受体和糖蛋白VI。这三种类型的受体在与胶原蛋白结合后均能独立触发多种信号通路。除了调节众多细胞反应外，整合素和盘状结构域受体还通过触发基质降解和更新来监测胶原细胞外基质的完整性。本文描述了一些最近在细胞微环境中发现的局部控制胶原蛋白、胶原蛋白结合受体和胶原蛋白降解蛋白酶表达的机制。
