Franco Christopher D, Hou Guangpei, Bendeck Michelle P
Department of Laboratory Medicine, University of Toronto, Ontario, Canada.
Trends Cardiovasc Med. 2002 May;12(4):143-8. doi: 10.1016/s1050-1738(01)00165-7.
The collagen matrix constitutes a major portion of the vascular extracellular matrix and imparts blood vessels with tensile strength and, even more important, modulates smooth muscle cell (SMC) responses via specific receptors and signaling pathways. This review is focused on the interactions of SMCs with the collagen matrix, how these interactions are involved in sensing the local environment, and the receptors that mediate these processes. Better understanding of the pathways involved in cell matrix interactions promises to provide novel therapeutic targets and treatment strategies for the prevention of arterial occlusive diseases such as atherosclerosis and restenosis.
胶原基质构成血管细胞外基质的主要部分，赋予血管抗张强度，更重要的是，通过特定受体和信号通路调节平滑肌细胞（SMC）反应。本综述聚焦于SMC与胶原基质的相互作用、这些相互作用如何参与感知局部环境以及介导这些过程的受体。更好地理解细胞与基质相互作用所涉及的途径有望为预防动脉闭塞性疾病（如动脉粥样硬化和再狭窄）提供新的治疗靶点和治疗策略。
