Laurencin C T, Ambrosio A M, Borden M D, Cooper J A
Center for Advanced Biomaterials and Tissue Engineering, Department of Chemical Engineering, Drexel University, Philadelphia, Pennsylvania 19104, USA.
Annu Rev Biomed Eng. 1999;1:19-46. doi: 10.1146/annurev.bioeng.1.1.19.
Because of an aging population and increased occurrence of sports-related injuries, musculoskeletal disorders have become one of the major health concerns in the United States. Current treatments, although fairly successful, do not provide the optimum therapy. These treatments typically rely on donor tissues obtained either from the patient or from another source. The former raises the issue of supply, whereas the latter poses the risk of rejection and disease transfer. This has prompted orthopedic surgeons and scientists to look for viable alternatives. In recent years, tissue engineering has gained increasing support as a method to treat orthopedic disorders. Because it uses principles of engineering, biology, and chemistry, tissue engineering may provide a more effective approach to the treatment of musculoskeletal disorders than traditional methods. This chapter presents a review of current methods and new tissue-engineering techniques for the treatment of disorders affecting bone, ligament, and cartilage.
由于人口老龄化以及与运动相关损伤的发生率增加，肌肉骨骼疾病已成为美国主要的健康问题之一。目前的治疗方法虽然相当成功，但并未提供最佳疗法。这些治疗通常依赖于从患者自身或其他来源获取的供体组织。前者引发了供应问题，而后者则带来了排斥反应和疾病传播的风险。这促使整形外科医生和科学家寻找可行的替代方案。近年来，组织工程作为一种治疗骨科疾病的方法获得了越来越多的支持。由于它运用了工程学、生物学和化学原理，与传统方法相比，组织工程可能为肌肉骨骼疾病的治疗提供更有效的途径。本章综述了目前治疗影响骨骼、韧带和软骨疾病的方法以及新的组织工程技术。
