纳米生物材料在骨科中的应用。

Nanobiomaterial applications in orthopedics.

作者信息

Christenson Elizabeth M, Anseth Kristi S, van den Beucken Jeroen J J P, Chan Casey K, Ercan Batur, Jansen John A, Laurencin Cato T, Li Wan-Ju, Murugan Ramalingam, Nair Lakshmi S, Ramakrishna Seeram, Tuan Rocky S, Webster Thomas J, Mikos Antonios G

机构信息

Department of Bioengineering-MS142, Rice University, PO Box 1892, Houston, Texas 77251-1892, USA.

出版信息

J Orthop Res. 2007 Jan;25(1):11-22. doi: 10.1002/jor.20305.

DOI:10.1002/jor.20305

PMID:17048259

Abstract

Advancements in nanobiotechnology are revolutionizing our capability to understand biological intricacies and resolve biological and medical problems by developing subtle biomimetic techniques. Nanocomposites and nanostructured materials are believed to play a pivotal role in orthopedic research since bone itself is a typical example of a nanocomposite. This article reviews current strategies using nanobiomaterials to improve current orthopedic materials and examines their applications in bone tissue engineering. Preliminary investigations support the potential of nanobiomaterials in orthopedic applications; however, significant advancements are necessary to achieve clinical use. Overall, current trends in nanobiotechnology foreshadow a bright future through the use of nanobiomaterials in the orthopedic domain.

摘要

纳米生物技术的进步正在彻底改变我们通过开发精妙的仿生技术来理解生物复杂性以及解决生物和医学问题的能力。纳米复合材料和纳米结构材料被认为在骨科研究中起着关键作用，因为骨骼本身就是纳米复合材料的典型例子。本文综述了利用纳米生物材料改进现有骨科材料的当前策略，并探讨了它们在骨组织工程中的应用。初步研究支持了纳米生物材料在骨科应用中的潜力；然而，要实现临床应用还需要取得重大进展。总体而言，纳米生物技术的当前趋势预示着通过在骨科领域使用纳米生物材料将拥有光明的未来。