Zwick M E, Cutler D J, Chakravarti A
Department of Genetics, and Center for Human Genetics, Case Western Reserve University School of Medicine, and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA.
Annu Rev Genomics Hum Genet. 2000;1:387-407. doi: 10.1146/annurev.genom.1.1.387.
This review discusses the prospects for understanding the genetic basis of complex traits in humans. We take the view that work done on Drosophila melanogaster can serve as a model for understanding complex traits in humans, and the literature on this model system, as well as on humans, is reviewed. The prospects for success in understanding the genetic basis of complex traits depend, in part, on the nature of the forces acting on genetic variation. We suggest that different experimental approaches should be undertaken for traits caused by common genetic variants versus those arising from rare genetic variants.
本综述探讨了理解人类复杂性状遗传基础的前景。我们认为，对黑腹果蝇所做的研究可以作为理解人类复杂性状的模型，并对该模型系统以及人类相关的文献进行了综述。理解复杂性状遗传基础的成功前景部分取决于作用于遗传变异的力量的性质。我们建议，对于由常见遗传变异引起的性状与由罕见遗传变异引起的性状，应采用不同的实验方法。
