Smith A G, Ramachandran P, Tripp S, Singleton J R
Department of Neurology, University of Utah, Salt Lake City, UT 84132, USA.
Neurology. 2001 Nov 13;57(9):1701-4. doi: 10.1212/wnl.57.9.1701.
The authors describe skin biopsy findings in patients with peripheral neuropathy associated with diabetes and impaired glucose tolerance (IGT). Six patients with IGT, eight with early diabetes-associated neuropathy, and five controls were recruited. Most subjects underwent nerve conduction studies (NCS) and quantitative sensory tests (QST). Skin biopsy was abnormal in all neuropathy subjects and correlated poorly with NCS. Neuropathy associated with IGT primarily affects small fibers and is similar to early diabetes-associated neuropathy.
作者描述了伴有糖尿病和糖耐量受损（IGT）的周围神经病变患者的皮肤活检结果。招募了6例IGT患者、8例早期糖尿病相关性神经病变患者和5例对照。大多数受试者接受了神经传导研究（NCS）和定量感觉测试（QST）。所有神经病变受试者的皮肤活检均异常，且与NCS相关性较差。与IGT相关的神经病变主要影响小纤维，与早期糖尿病相关性神经病变相似。
