Department of Endocrinology, The Second Affiliated Hospital of Soochow University, 1055 San-Xiang Road, Suzhou, 215000, China.
Department of Endocrinology, Hulunbeir People's Hospital, Hulunbuir, China.
BMC Ophthalmol. 2023 Nov 15;23(1):460. doi: 10.1186/s12886-023-03181-z.
To quantify corneal nerve fiber parameters in a Mongolian population with diabetic peripheral neuropathy (DPN) by corneal confocal microscopy.
This study conducted a comprehensive evaluation of 114 participants from Hulunbuir between January 2020 and December 2021. The participants included healthy controls, Mongolian and Han patients with type 2 diabetes mellitus. Demographic, medical, and laboratory data were collected, and neuropathy was evaluated by confocal corneal microscopy. And compare various parameters between Han and Mongolian were performed using SPSS software.
The average waist circumference of Mongolian diabetic patients was larger than that of Han diabetic patients (P < 0.05). The mean HbA1c of Mongolian was 9.30 (8.15, 10.30) %, and that of Han was 8.30 (7.20, 9.40) % (P = 0.023). The average values of Corneal Nerve Fiber Density (CNFD), Corneal Nerve Fiber Length (CNFL) and corneal nerve branch density (CNBD) in Mongolian diabetic patients were significantly lower than those in Han diabetic patients (P < 0.05). The correlation coefficient between CNFL and age was - 0.368. ROC results show that CNBD has a certain diagnostic value for DPN in Mongolian patients with type 2 diabetes and the optimal cut-off point value is 24.99(no./mm), the sensitivity is 80.0%, and the specificity is 77.8%.
The corneal confocal microscopy could possibly represent a promising adjuvant technique for the early diagnosis and assessment of PDN in Mongolian T2DM patients.
通过角膜共焦显微镜量化患有糖尿病周围神经病变（DPN）的蒙古族人群的角膜神经纤维参数。
本研究对 2020 年 1 月至 2021 年 12 月期间来自呼伦贝尔的 114 名参与者进行了全面评估。参与者包括健康对照组、蒙古族和汉族 2 型糖尿病患者。收集人口统计学、医学和实验室数据，并通过共焦角膜显微镜评估神经病变。使用 SPSS 软件比较汉族和蒙古族之间的各种参数。
蒙古族糖尿病患者的平均腰围大于汉族糖尿病患者（P < 0.05）。蒙古族的平均 HbA1c 为 9.30（8.15，10.30）%，汉族为 8.30（7.20，9.40）%（P = 0.023）。蒙古族糖尿病患者的角膜神经纤维密度（CNFD）、角膜神经纤维长度（CNFL）和角膜神经分支密度（CNBD）平均值明显低于汉族糖尿病患者（P < 0.05）。CNFL 与年龄的相关系数为-0.368。ROC 结果表明，CNBD 对蒙古族 2 型糖尿病患者 DPN 具有一定的诊断价值，最佳截断值为 24.99（个/mm），灵敏度为 80.0%，特异性为 77.8%。
角膜共焦显微镜可能是蒙古族 2 型糖尿病患者 DPN 早期诊断和评估的一种有前途的辅助技术。
