与钾离子通道抗体相关的持续性面部肌束震颤

Persistent facial myokymia associated with K(+) channel antibodies.

作者信息

Gutmann L, Tellers J G, Vernino S

机构信息

Department of Neurology, West Virginia University, Morgantown 26506, USA.

出版信息

Neurology. 2001 Nov 13;57(9):1707-8. doi: 10.1212/wnl.57.9.1707.

DOI:10.1212/wnl.57.9.1707

PMID:11706117

Abstract

A 58-year-old woman developed bilateral facial myokymia in 1978, persisting for the next 23 years and associated with high titers of voltage-gated K(+) channel (VGKC) antibodies. Brain imaging failed to show a pontine lesion. The clinical facial myokymia and electromyographic doublets and multiplets (43 to 250 Hz) were milder and more restricted than those seen in generalized neuromyotonic disorders with VGKC antibodies. This case and another reported recently represent a focal VGKC antibody syndrome.

摘要

一名58岁女性于1978年出现双侧面部肌束震颤，持续了接下来的23年，并伴有高滴度的电压门控钾通道（VGKC）抗体。脑部影像学检查未显示脑桥病变。与伴有VGKC抗体的全身性神经肌强直障碍相比，该患者的临床面部肌束震颤以及肌电图上的双峰和多峰放电（43至250赫兹）程度较轻且范围更局限。该病例以及最近报道的另一例病例代表了一种局限性VGKC抗体综合征。