Tamanoi F, Gau C L, Jiang C, Edamatsu H, Kato-Stankiewicz J
Department of Microbiology and Molecular Genetics, Jonsson Comprehensive Cancer Center, University of California Los Angeles, 90095-1489, USA.
Cell Mol Life Sci. 2001 Oct;58(11):1636-49. doi: 10.1007/PL00000802.
Protein farnesylation, catalyzed by protein farnesyltransferase, plays important roles in the membrane association and protein-protein interaction of a number of eukaryotic proteins. Recent development of farnesyltransferase inhibitors (FTIs) has led to further insight into the biological significance of farnesylation in cancer cells. A number of reports point to the dramatic effects FTIs exert on cancer cells. In addition to inhibiting anchorage-independent growth, FTIs cause changes in the cell cycle either at the G1/S or at the G2/M phase. Furthermore, induction of apoptosis by FTIs has been reported. FTIs also affects the actin cytoskeleton and cell morphology. This review summarizes these reports and discusses implications for farnesylated proteins responsible for these FTI effects.
由蛋白质法尼基转移酶催化的蛋白质法尼基化在许多真核蛋白质的膜结合和蛋白质-蛋白质相互作用中发挥着重要作用。法尼基转移酶抑制剂（FTIs）的最新进展使人们对法尼基化在癌细胞中的生物学意义有了更深入的了解。许多报告指出了FTIs对癌细胞产生的显著影响。除了抑制非贴壁依赖性生长外，FTIs还会在G1/S期或G2/M期引起细胞周期的变化。此外，已有报道称FTIs可诱导细胞凋亡。FTIs还会影响肌动蛋白细胞骨架和细胞形态。本综述总结了这些报告，并讨论了对导致这些FTI效应的法尼基化蛋白质的影响。
