Yamasaki M, Yayoi E, Kishibuchi M, Nishi T, Yagyu T, Kawasaki K, Ostapenko V, Nishide T
Dept. of Surgery, Kaizuka City Hospital.
Gan To Kagaku Ryoho. 2001 Oct;28(11):1746-8.
A 59-year-old woman was admitted to our hospital because of massive bleeding from a right breast tumor. The breast tumor had existed for ten years occupied the entire right breast (23 x 20 cm), its central part forming an ulcer 17 x 15 cm in size. Radiotherapy to the right breast and medication with tamoxifen were started, after which five courses of CMF chemotherapy were given. The tumor decreased to 16 x 14 cm, and hyperthermia to the right breast was performed for a total of 87 sessions from January 1999. The irregular protruding portion of the ulcer caused the necrosis, and was sloughed off about one month after hyperthermia. No viable tumor cells were observed in a biopsy taken at 5 months after the start of treatment (40 sessions). A total of 87 hyperthermia sessions were performed, and the ulcer disappeared. For 15 months after the end of hyperthermia, the patient showed a continuous CR. Hyperthermia in combination with radiotherapy or chemotherapy for breast cancer may produce a remarkable effect as in the present case, and may become one choice for medical treatment of locally advanced or recurrent breast cancer.
一名59岁女性因右乳肿瘤大量出血入住我院。该乳腺肿瘤已存在十年，占据整个右乳（23×20厘米），其中心部分形成一个17×15厘米大小的溃疡。开始对右乳进行放疗并使用他莫昔芬治疗，之后进行了五个疗程的CMF化疗。肿瘤缩小至16×14厘米，从1999年1月开始对右乳进行了总共87次热疗。溃疡的不规则突出部分导致坏死，并在热疗后约一个月脱落。治疗开始后5个月（40次治疗）进行的活检未观察到存活的肿瘤细胞。共进行了87次热疗，溃疡消失。热疗结束后的15个月里，患者持续完全缓解。热疗联合放疗或化疗治疗乳腺癌可能如本例一样产生显著效果，可能成为局部晚期或复发性乳腺癌治疗的一种选择。
