Roti Roti J L, Dethlefsen L A
Cell Tissue Kinet. 1975 Jul;8(4):321-33. doi: 10.1111/j.1365-2184.1975.tb01497.x.
Steady state crypt cell kinetics have been simulated using matrix algebra. The model crypt cell population is distributed through two proliferation compartments (P1 and P2) and a quiescent state (Q). Under steady state conditions half the daughter cells produced on completion of P1 enter G1 of P2 and half enter G1 of P1. Both P2 daughter cells enter Q. Cells in Q are non-dividing but retain the potential to divide. On completion of Q, cells lose the potential to divide and move up onto the villi. The model has been developed by simultaneously simulating the following biological data: (1) the per cent labeled mitosis (PML) curve, (2) the number of labeled cells per crypt as a function of time following an injection of 3H-thymidine, and (3) the total number of cells per crypt.
已使用矩阵代数对稳态隐窝细胞动力学进行了模拟。模型中的隐窝细胞群体分布在两个增殖区室（P1和P2）和一个静止状态（Q）中。在稳态条件下，P1完成时产生的子代细胞中有一半进入P2的G1期，另一半进入P1的G1期。P2的两个子代细胞都进入Q期。处于Q期的细胞不进行分裂，但保留分裂潜能。Q期结束时，细胞失去分裂潜能并向上迁移至绒毛。该模型是通过同时模拟以下生物学数据而开发的：（1）标记有丝分裂百分比（PML）曲线，（2）注射3H-胸腺嘧啶核苷后每个隐窝中标记细胞数量随时间的变化，以及（3）每个隐窝中的细胞总数。
