Borrell J, Lloréns I, Borrell S
Eur J Pharmacol. 1975 Apr;31(2):237-42. doi: 10.1016/0014-2999(75)90045-x.
Corticosteroids and ascorbic acid in the adrenal glands of adult cats have been investigated after single or repeated administration of morphine. Also plasma levels and urinary excretion of corticosteroids were determined. A significant increase in the content of corticosteroids in the glands and plasma was found after initial injection of morphine. After 7 days of consecutive morphine treatment a fall of corticosteroids in the glands was observed; after 2 weeks of daily injections the content of adrenal corticosteroids was significantly lower than in the control animals but no change was found in the plasma. Administration of the drug during 1 month led to a highly significant decrease of corticosteroids in the glands as well as in plasma. No significant change in adrenal ascorbic acids was found whether the adrenal corticosteroids were higher or lower than in the control cats. Urinary corticosteroids were high during the first week of morphine treatment but thereafter the excretion declined progressively and was lower than the control level after 13 days of treatment. The significant decrease of corticosteroids observed after repeated administration of morphine and the rise in adrenal corticosteroids found after the injection of nalorphine to the morphinized animals suggest that some kind of morphine dependence had been developed in the cats after repeated administration of the drug.
在成年猫单次或多次注射吗啡后，对其肾上腺中的皮质类固醇和抗坏血酸进行了研究。同时还测定了血浆中皮质类固醇水平和尿中皮质类固醇排泄量。首次注射吗啡后，发现肾上腺和血浆中皮质类固醇含量显著增加。连续7天注射吗啡后，观察到肾上腺中皮质类固醇含量下降；每日注射2周后，肾上腺皮质类固醇含量显著低于对照动物，但血浆中未发现变化。给药1个月导致肾上腺和血浆中皮质类固醇含量极显著下降。无论肾上腺皮质类固醇含量高于还是低于对照猫，肾上腺抗坏血酸均未发现显著变化。吗啡治疗第一周尿中皮质类固醇含量较高，但此后排泄量逐渐下降，治疗13天后低于对照水平。多次注射吗啡后观察到的皮质类固醇显著下降以及向吗啡依赖动物注射烯丙吗啡后肾上腺皮质类固醇的升高表明，多次给药后猫体内已产生某种吗啡依赖性。
