Zhang S Q, Inoué S, Kimura M
Department of Biocybernetics, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Neuroreport. 2001 Oct 29;12(15):3173-6. doi: 10.1097/00001756-200110290-00006.
The present study examines whether or not prolactin-releasing peptide (PrRP) infused intracerebroventricularly (i.c.v.) affects sleep and the release of prolactin (PRL) and growth hormone (GH) in rats. At a dose of 0.1 nmol, PrRP promoted rapid-eye-movement (REM) sleep, whereas 1.0 nmol increased both non-REM and REM sleep and 10.0 nmol enhanced only non-REM sleep. During the i.c.v. infusion of PrRP with 0.1 nmol, levels of plasma PRL were elevated, but GH levels were significantly decreased. Since it is reported that PrRP fails to induce PRL release from the male pituitary, the stimulatory effects of PrRP on PRL release observed here seem to be indirect. However, PRL stimulated by i.c.v.-infused PrRP could take part in the REM sleep-promoting activity of PrRP.
本研究探讨脑室内注射催乳素释放肽（PrRP）是否会影响大鼠的睡眠以及催乳素（PRL）和生长激素（GH）的释放。剂量为0.1 nmol时，PrRP可促进快速眼动（REM）睡眠，而1.0 nmol可增加非快速眼动睡眠和快速眼动睡眠，10.0 nmol仅增强非快速眼动睡眠。在脑室内注射0.1 nmol PrRP的过程中，血浆PRL水平升高，但GH水平显著降低。由于有报道称PrRP不能诱导雄性垂体释放PRL，因此此处观察到的PrRP对PRL释放的刺激作用似乎是间接的。然而，脑室内注射PrRP刺激产生的PRL可能参与了PrRP促进REM睡眠的活动。
