Fatemi S H, Earle J A, Stary J M, Lee S, Sedgewick J
Department of Psychiatry, University of Minnesota Medical School, Box 392, Mayo Building, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Neuroreport. 2001 Oct 29;12(15):3257-62. doi: 10.1097/00001756-200110290-00023.
SNAP-25 levels were measured in ventral hippocampus in subjects with unipolar depression (n = 12), bipolar disorder (n = 13), schizophrenia (n = 15) and controls (n = 15) using quantitative immunocytochemistry. SNAP-25 levels were reduced significantly in stratum oriens of bipolar patients compared with controls (p < 0.05); they were also reduced significantly in st. oriens (p < 0.01 vs schizophrenia), in alveous (p < 0.01 vs schizophrenia) and in presubiculum (p < 0.05 vs depressed). SNAP-25 levels were also reduced in several layers of schizophrenics, only significantly so in st. granulosum (p < 0.05 vs controls). In contrast, depressed SNAP-25 levels increased in st. moleculare (p < 0.01 vs schizophrenics) and presubiculum (p < 0.05 vs controls and bipolars; p < 0.01 vs schizophrenics). SNAP-25 values were not affected by age, sex, race, post-mortem interval, brain pH, side of brain, age of onset of disease, family history of psychiatric disease, drug or alcohol use, antipsychotic drug treatment, or mode of death. The reported changes in SNAP-25 levels appear to be disease specific, separating synaptic pathology in unipolar depression from that observed in schizophrenia and bipolar disorders.
采用定量免疫细胞化学方法，对单相抑郁症患者（n = 12）、双相情感障碍患者（n = 13）、精神分裂症患者（n = 15）及对照组（n = 15）腹侧海马中的SNAP - 25水平进行了检测。与对照组相比，双相情感障碍患者的内嗅层SNAP - 25水平显著降低（p < 0.05）；在内嗅层（与精神分裂症患者相比，p < 0.01）、海马槽（与精神分裂症患者相比，p < 0.01）和前扣带回（与抑郁症患者相比，p < 0.05）中，SNAP - 25水平也显著降低。精神分裂症患者的几层结构中SNAP - 25水平也有所降低，仅颗粒层显著降低（与对照组相比，p < 0.05）。相比之下，抑郁症患者的分子层（与精神分裂症患者相比，p < 0.01）和前扣带回（与对照组和双相情感障碍患者相比，p < 0.05；与精神分裂症患者相比，p < 0.01）中SNAP - 25水平升高。SNAP - 25值不受年龄、性别、种族、死后间隔时间、脑pH值、脑的侧别、疾病发病年龄、精神疾病家族史、药物或酒精使用、抗精神病药物治疗或死亡方式的影响。所报道的SNAP - 25水平变化似乎具有疾病特异性，将单相抑郁症的突触病理学与精神分裂症和双相情感障碍中观察到的突触病理学区分开来。
