Damadzic Ruslan, Shuangshoti Shanop, Giblen Georgeta, Herman Mary M
Section of Neuropathology, Clinical Brain Disorders Branch, Building 36, Room 3A24, 36 Convent Drive, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-4091, USA.
Acta Neuropathol. 2002 May;103(5):488-94. doi: 10.1007/s00401-001-0496-2. Epub 2002 Jan 31.
Earlier reports have provided conflicting results regarding the association between Alzheimer's disease (AD) and mental disorders. Using a well-characterized postmortem series of 40 middle-aged human brains, we have performed quantitative analysis of neurofibrillary tangles and senile plaques in the entorhinal cortex, subiculum and rostral hippocampus in 9 subjects with schizophrenia, 8 with bipolar disorder, 12 with depression, and 11 age- and sex-matched controls. No significant differences were found among the four groups. Our study indicates that the Alzheimer-type changes, which might be related to the likelihood of AD development later in life, are not increased in middle-aged subjects with mental illness. The result also supports the more recent reports that have demonstrated no increased incidence of AD in mentally ill patients.
早期报告对于阿尔茨海默病（AD）与精神障碍之间的关联给出了相互矛盾的结果。我们利用一组特征明确的40例中年人脑尸检样本，对9例精神分裂症患者、8例双相情感障碍患者、12例抑郁症患者以及11例年龄和性别匹配的对照者的内嗅皮质、海马下托和喙侧海马中的神经原纤维缠结和老年斑进行了定量分析。四组之间未发现显著差异。我们的研究表明，可能与晚年发生AD可能性相关的阿尔茨海默病型改变，在患有精神疾病的中年受试者中并未增加。该结果也支持了最近那些表明精神病患者中AD发病率未增加的报告。
