Reimold E W
JPEN J Parenter Enteral Nutr. 1979 Sep-Oct;3(5):335-40. doi: 10.1177/014860717900300503.
Biochemical changes were monitored during fat infusion as part of an evaluation of the toxicity that accompanies the intravenous administration of a new soybean oil emulsion in dogs. Beagles were given FE-S15 at 9 and 4 g/kg/day for 28 days via a central venous catheter. The total serum lipid, triglyceride, and phospholipid concentrations of the animals receiving fat in high doses increased 3 to 4 times in comparison to that of the control group; cholesterol increased 5 times. The rise of serum lipid fractions was proportionally smaller in animals receiving the low dose fat infusion. All values returned to the control range 2 wks after termination of the infusion. The serum protein level fell from 6.5 to 5.1 g/dl in animals given 9 g/kg/day fat while animals receiving 4 g/kg/day had a significant increase to 8.4 g/dl (day 27). In comparison with the control groups, the animals receiving low dose fat infusion also had a significant rise in serum albumin and, to a lesser degree, in alpha and beta globulins. A rise in alkaline phosphatase activity was observed in all dogs receiving fat infusion, but was significantly different from the controls only in animals on high dose fat infusion. None of the other monitored biochemical serum values were affected by the administered fat and there was no evidence of disturbance in liver function.
在脂肪输注过程中监测生化变化，作为对犬静脉注射一种新型大豆油乳剂伴随的毒性进行评估的一部分。通过中心静脉导管，给予比格犬FE - S15，剂量分别为9和4 g/kg/天，持续28天。与对照组相比，高剂量接受脂肪输注的动物血清总脂质、甘油三酯和磷脂浓度增加了3至4倍；胆固醇增加了5倍。低剂量脂肪输注动物的血清脂质组分升高幅度相对较小。输注终止2周后，所有数值均恢复到对照范围。给予9 g/kg/天脂肪的动物血清蛋白水平从6.5降至5.1 g/dl，而接受4 g/kg/天的动物在第27天血清蛋白水平显著升高至8.4 g/dl。与对照组相比，低剂量脂肪输注的动物血清白蛋白也显著升高，α和β球蛋白也有较小程度的升高。所有接受脂肪输注的犬均观察到碱性磷酸酶活性升高，但仅高剂量脂肪输注的动物与对照组有显著差异。其他监测的血清生化值均未受所给脂肪的影响，也没有肝功能紊乱的证据。
