Chang P F, Arendt-Nielsen L, Graven-Nielsen T, Svensson P, Chen A C
Human Brain Mapping and Cortical Imaging Laboratory, Center for Sensory-Motor Interaction, Aalborg University, Fredrik Bajers Vej 7 D-3, 9220 Aalborg, Denmark.
Exp Brain Res. 2001 Nov;141(2):195-203. doi: 10.1007/s002210100864.
To clarify the specific effects of muscle pain on electroencephalogram (EEG) activation in man, painful and non-painful sensations were produced by intramuscular injections of capsaicin and vehicle solution in the left brachioradialis muscle, with identical procedures in 15 male volunteers. Thirty-one channel EEG data acquired before, during and after the two injections were analysed and compared in respect of topography and power spectrum. Although the painful and non-painful muscular stimulations evoked similar EEG topographic patterns, statistics demonstrated that distinct EEG activation over different areas of the head were induced by the painful and non-painful stimulation compared with the baselines. The decreases in theta and alpha-1 (8-10.5 Hz) activity in central and posterior parietal parts were evoked by non-painful stimulation, but the decreases in alpha-1 and alpha-2 (11-13.5 Hz) activities in the posterior part of the head were induced by painful stimulation. The alpha-2 activity augmented during the waning pain following a decrease in the overt pain. Comparing the EEG changes between baseline, non-painful and painful stimulations as well as waning pain, we found that the increase in beta-2 activity during muscle pain was significant over the extensive areas of the head, whereas a significant increase in alpha-2 activity took place at the posterior part of the head during waning pain following a marked decrease in overt pain. These results may imply that the painful and non-painful muscular stimulations evoke distinct EEG activation in different neural networks of the human brain and the intensity of nociceptive input from muscle may encode the variety of topographic EEG changes.
为了阐明肌肉疼痛对人体脑电图（EEG）激活的具体影响，通过向15名男性志愿者的左侧肱桡肌内注射辣椒素和赋形剂溶液来产生疼痛和非疼痛感觉，并采用相同的程序。对两次注射前、注射期间和注射后的31通道EEG数据进行了分析，并在地形图和功率谱方面进行了比较。尽管疼痛和非疼痛的肌肉刺激诱发了相似的EEG地形图模式，但统计结果表明，与基线相比，疼痛和非疼痛刺激在头部不同区域诱发了明显的EEG激活。非疼痛刺激引起中央和顶叶后部的θ波和α-1（8-10.5Hz）活动降低，但疼痛刺激引起头部后部的α-1和α-2（11-13.5Hz）活动降低。在明显疼痛减轻后的疼痛消退过程中，α-2活动增强。比较基线、非疼痛和疼痛刺激以及疼痛消退期间的EEG变化，我们发现在肌肉疼痛期间，β-2活动在头部广泛区域的增加是显著的，而在明显疼痛显著减轻后的疼痛消退期间，α-2活动在头部后部显著增加。这些结果可能意味着疼痛和非疼痛的肌肉刺激在人类大脑的不同神经网络中诱发了不同的EEG激活，并且来自肌肉的伤害性输入强度可能编码了EEG地形图变化的多样性。
