Chang Peng Fei, Arendt-Nielsen Lars, Chen Andrew C N
Human Brain Mapping and Cortical Imaging Laboratory, Center for Sensory-Motor Interaction, Aalborg University, Fredrik Bajers Vej 7-D-3, 9220 Aalborg, Denmark.
Exp Brain Res. 2002 Dec;147(3):387-93. doi: 10.1007/s00221-002-1272-9. Epub 2002 Oct 17.
The specificity of electroencephalogram (EEG) activity in relation to processing of human pain needs further elucidation. This study was designed to determine if nociceptive input and general arousal responses to external stimulation exert different effects on EEG activity. Continuous aversive auditory stimuli (90 dB for 2 min) and painful injection of hypertonic saline (5.8%, 0.2 ml) into the left brachioradialis muscle were administered to 12 male subjects during separate sessions in a counterbalanced design. Intensity, arousal and unpleasantness were assessed during the muscle pain and auditory stimulation using a visual analogue scale and arousal-affective scales. The EEG data (32 channels) was acquired before, during and after application of painful and aversive auditory stimuli. Aversive auditory stimulation and intramuscular injection of hypertonic saline induced similar degrees of arousal and unpleasantness associated with a similarity of intensity of sensation of pain and auditory sensation. However, muscle pain induced a significant decrease of alpha-1 activity (8-14 Hz) at T6, PC2, PC6, Pz, P4, O2 and POz sites compared to the baseline, but aversive auditory stimulation did not produce any significant changes in alpha-1 activity compared to baseline. The alpha-1 EEG powers at P3, Pz, P4, PC1, PC2 and POz, and alpha-2 at Pz and POz sites were significantly decreased during muscle pain when compared with aversive noise stimulation. These results indicate that specific EEG patterns are associated with human pain processing.
脑电图（EEG）活动与人类疼痛处理之间的特异性关系尚需进一步阐明。本研究旨在确定伤害性输入和对外部刺激的一般唤醒反应是否对EEG活动产生不同影响。在一项平衡设计的单独实验环节中，对12名男性受试者分别施加持续的厌恶听觉刺激（90分贝，持续2分钟）以及向左侧肱桡肌注射高渗盐水（5.8%，0.2毫升）造成疼痛。在肌肉疼痛和听觉刺激过程中，使用视觉模拟量表和唤醒-情感量表评估强度、唤醒程度和不愉快程度。在施加疼痛和厌恶听觉刺激之前、期间和之后采集EEG数据（32通道）。厌恶听觉刺激和肌肉注射高渗盐水引起的唤醒程度和不愉快程度相似，疼痛和听觉感觉强度也相似。然而，与基线相比，肌肉疼痛导致T6、PC2、PC6、Pz、P4、O2和POz部位的α-1活动（8-14赫兹）显著降低，但厌恶听觉刺激与基线相比未使α-1活动产生任何显著变化。与厌恶噪声刺激相比，肌肉疼痛期间P3、Pz、P4、PC1、PC2和POz部位的α-1 EEG功率以及Pz和POz部位的α-2 EEG功率显著降低。这些结果表明特定的EEG模式与人类疼痛处理相关。
